The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies

• Published in: EBioMedicine Vol. 62; p. 103102
• Main Authors: Martin, Alyssa R., Patel, Eshan U., Kirby, Charles, Astemborski, Jacquie, Kirk, Gregory D., Mehta, Shruti H., Marshall, Kyle, Janes, Holly, Clayton, Ashley, Corey, Lawrence, Hammer, Scott M., Sobieszczyk, Magdalena E., Arthos, James, Cicala, Claudia, Redd, Andrew D., Quinn, Thomas C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2020; Elsevier
• Subjects: Advanced Basic Science; Internal Medicine; Research Paper

α4β7 is a gut-homing integrin heterodimer that can act as a non-essential binding molecule for HIV. A previous study in heterosexual African women found that individuals with higher proportions of α4β7 expressing CD4+ T cells were more likely to become infected with HIV, as well as present with fast...