Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites - Lalovic, Bojan; Kharasch, Evan; Hoffer, Christine; Risler, Linda; Liu-Chen, Lee-Yuan; Shen, Danny D (Clinical pharmacology and therapeutics, 2006)
Keywords: Administration, Oral; Adult; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - pharmacokinetics; Analgesics, Opioid - pharmacology; Animals; Brain - metabolism; CHO Cells; Cricetinae; Cricetulus; Female; Half-Life; Humans; Male; Oxidation-Reduction; Oxycodone - administration & dosage; Oxycodone - pharmacokinetics; Oxycodone - pharmacology; Pilot Projects; Pupil - drug effects; Radioligand Assay; Rats; Receptors, Opioid - metabolism; Tissue Distribution