Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo

• Published in: Circulation research Vol. 117; no. 4; pp. 376 - 387
• Main Authors: Urtz, Nicole, Gaertner, Florian, von Bruehl, Marie-Luise, Chandraratne, Sue, Rahimi, Faridun, Zhang, Lin, Orban, Mathias, Barocke, Verena, Beil, Johannes, Schubert, Irene, Lorenz, Michael, Legate, Kyle R, Huwiler, Andrea, Pfeilschifter, Josef M, Beerli, Christian, Ledieu, David, Persohn, Elke, Billich, Andreas, Baumruker, Thomas, Schnitzler, Michael Mederos y, Massberg, Steffen
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 31.07.2015
• Subjects: Animals; Arachidonic Acid - blood; Blood Coagulation; Blood Coagulation Tests; Blood Platelets - enzymology; Carotid Artery Injuries - blood; Carotid Artery Injuries - enzymology; Disease Models, Animal; Erythrocytes - enzymology; Lysophospholipids - blood; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor) - blood; Phosphotransferases (Alcohol Group Acceptor) - deficiency; Phosphotransferases (Alcohol Group Acceptor) - genetics; Platelet Adhesiveness; Platelet Aggregation; Platelet Function Tests; Receptors, Lysosphingolipid - blood; Signal Transduction; Sphingosine - analogs & derivatives; Sphingosine - blood; Thrombosis - blood; Thrombosis - enzymology; Thrombosis - prevention & control; Thromboxane A2 - blood; Vascular System Injuries - blood; Vascular System Injuries - enzymology; blood platelets; thrombosis; sphingosine 1-phosphate; sphingosine kinase; platelet aggregation

RATIONALE:Platelets are known to play a crucial role in hemostasis. Sphingosine kinases (Sphk) 1 and 2 catalyze the conversion of sphingosine to the bioactive metabolite sphingosine 1-phosphate (S1P). Although platelets are able to secrete S1P on activation, little is known about a potential intrins...