Lymphocytes subsets reference values in childhood
Immunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in the diagnostic process of primary immunodeficiency diseases, its use becoming more and more widespread as the knowledge about these illnesses increases. However, the availability of reliable reference values, whi...
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| Published in | Cytometry. Part A Vol. 87; no. 1; pp. 81 - 85 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.01.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Immunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in the diagnostic process of primary immunodeficiency diseases, its use becoming more and more widespread as the knowledge about these illnesses increases. However, the availability of reliable reference values, which need to be age‐matched for the pediatric population, is a pre‐requisite for the reliable interpretation of immunophenotyping data. Aim of this study is to analyze the lymphocyte subsets and activation markers distribution in children aged 0–18 years referring to the University Hospital of Padova and to create age‐matched reference values expressed by percentiles, thus providing a valuable guideline for the interpretation of the immunophenotype. © 2014 International Society for Advancement of Cytometry |
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| AbstractList | Immunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in the diagnostic process of primary immunodeficiency diseases, its use becoming more and more widespread as the knowledge about these illnesses increases. However, the availability of reliable reference values, which need to be age-matched for the pediatric population, is a pre-requisite for the reliable interpretation of immunophenotyping data. Aim of this study is to analyze the lymphocyte subsets and activation markers distribution in children aged 0-18 years referring to the University Hospital of Padova and to create age-matched reference values expressed by percentiles, thus providing a valuable guideline for the interpretation of the immunophenotype.Immunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in the diagnostic process of primary immunodeficiency diseases, its use becoming more and more widespread as the knowledge about these illnesses increases. However, the availability of reliable reference values, which need to be age-matched for the pediatric population, is a pre-requisite for the reliable interpretation of immunophenotyping data. Aim of this study is to analyze the lymphocyte subsets and activation markers distribution in children aged 0-18 years referring to the University Hospital of Padova and to create age-matched reference values expressed by percentiles, thus providing a valuable guideline for the interpretation of the immunophenotype. Immunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in the diagnostic process of primary immunodeficiency diseases, its use becoming more and more widespread as the knowledge about these illnesses increases. However, the availability of reliable reference values, which need to be age-matched for the pediatric population, is a pre-requisite for the reliable interpretation of immunophenotyping data. Aim of this study is to analyze the lymphocyte subsets and activation markers distribution in children aged 0-18 years referring to the University Hospital of Padova and to create age-matched reference values expressed by percentiles, thus providing a valuable guideline for the interpretation of the immunophenotype. Immunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in the diagnostic process of primary immunodeficiency diseases, its use becoming more and more widespread as the knowledge about these illnesses increases. However, the availability of reliable reference values, which need to be age-matched for the pediatric population, is a pre-requisite for the reliable interpretation of immunophenotyping data. Aim of this study is to analyze the lymphocyte subsets and activation markers distribution in children aged 0-18 years referring to the University Hospital of Padova and to create age-matched reference values expressed by percentiles, thus providing a valuable guideline for the interpretation of the immunophenotype. copyright 2014 International Society for Advancement of Cytometry Immunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in the diagnostic process of primary immunodeficiency diseases, its use becoming more and more widespread as the knowledge about these illnesses increases. However, the availability of reliable reference values, which need to be age‐matched for the pediatric population, is a pre‐requisite for the reliable interpretation of immunophenotyping data. Aim of this study is to analyze the lymphocyte subsets and activation markers distribution in children aged 0–18 years referring to the University Hospital of Padova and to create age‐matched reference values expressed by percentiles, thus providing a valuable guideline for the interpretation of the immunophenotype. © 2014 International Society for Advancement of Cytometry |
| Author | Sanzari, M.C. Basso, G. Tosato, F. Pantano, G. Putti, M. C. Plebani, M. Bucciol, G. |
| Author_xml | – sequence: 1 givenname: F. surname: Tosato fullname: Tosato, F. organization: University Hospital of Padova – sequence: 2 givenname: G. surname: Bucciol fullname: Bucciol, G. organization: University Hospital of Padova – sequence: 3 givenname: G. surname: Pantano fullname: Pantano, G. organization: University Hospital of Padova – sequence: 4 givenname: M. C. surname: Putti fullname: Putti, M. C. organization: University Hospital of Padova – sequence: 5 givenname: M.C. surname: Sanzari fullname: Sanzari, M.C. organization: University Hospital of Padova – sequence: 6 givenname: G. surname: Basso fullname: Basso, G. organization: University Hospital of Padova – sequence: 7 givenname: M. surname: Plebani fullname: Plebani, M. organization: University Hospital of Padova |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25132325$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adolescent Antigens, CD - immunology Child Child, Preschool Common Variable Immunodeficiency - diagnosis Common Variable Immunodeficiency - immunology Common Variable Immunodeficiency - pathology Female Flow Cytometry Humans Immunophenotyping Infant Infant, Newborn Lymphocyte Count lymphocyte subsets Lymphocyte Subsets - cytology Lymphocyte Subsets - immunology Male pediatric population primary immunodeficiencies Reference Values |
| Title | Lymphocytes subsets reference values in childhood |
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