Pharmacodynamics of converting enzyme inhibition: the cardiovascular, endocrine and autonomic effects of MK421 (enalapril) and MK521

• Published in: British journal of clinical pharmacology Vol. 14; no. 3; pp. 347 - 355
• Main Authors: Millar, JA, Derkx, FH, McLean, K, Reid, JL
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.1982
• Subjects: Adult; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen - blood; Autonomic Nervous System - drug effects; Blood Pressure - drug effects; Cardiovascular System - drug effects; Catecholamines - blood; Dipeptides - pharmacology; Enalapril; Endocrine Glands - drug effects; Humans; Lisinopril; Male; Middle Aged; Renin - blood

1 Two new orally active inhibitors of angiotensin converting enzyme MK421 (enalapril maleate) and its lysine analogue MK521 were given to nine salt-replete normal subjects in a randomised placebo-controlled study. 2 Supine and erect blood pressure and heart rate were measured before (0) and 1, 2, 4,...