Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin–proteasome system in pancreatic beta cell dysfunction - Bugliani, Marco; Liechti, Robin; Cheon, Hwanju; Suleiman, Mara; Marselli, Lorella; Kirkpatrick, Clare; Filipponi, Franco; Boggi, Ugo; Xenarios, Ioannis; Syed, Farooq; Ladriere, Laurence; Wollheim, Claes; et al. (Molecular and cellular endocrinology, 2013)
Keywords: Aged; Animals; Beta cells; Cell Line; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - physiopathology; Female; gene expression; Gene Expression Profiling; gene expression regulation; Gene Expression Regulation - drug effects; genes; Humans; Immunohistochemistry; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Lipotoxicity; Male; Microarray; microarray technology; Middle Aged; noninsulin-dependent diabetes mellitus; Oligonucleotide Array Sequence Analysis; Palmitates - pharmacology; phenotype; proteasome endopeptidase complex; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; Proteasome Inhibitors - pharmacology; protein degradation; Rats; Reverse Transcriptase Polymerase Chain Reaction; transcriptome; Transcriptome - genetics; Type 2 diabetes; ubiquitin; Ubiquitin - genetics; Ubiquitin - metabolism; Ubiquitinated Proteins - genetics; Ubiquitinated Proteins - metabolism; Ubiquitin–proteasome system; Beta cells; Type 2 diabetes; Microarray; Lipotoxicity; Ubiquitin–proteasome system