Evidence of multiple point mutations in Theileria annulata cytochrome b gene incriminated in buparvaquone treatment failure

• Published in: Acta tropica Vol. 191; pp. 128 - 132
• Main Authors: Chatanga, Elisha, Mosssad, Ehab, Abdo Abubaker, Hazem, Amin Alnour, Sondos, Katakura, Ken, Nakao, Ryo, Salim, Bashir
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019
• Subjects: alanine; binding sites; blood sampling; Buparvaquone; cattle; cytochrome b; disease outbreaks; DNA; drug resistance; genes; glycine (amino acid); methionine; point mutation; polymerase chain reaction; Resistance; serine; Sudan; Theileria annulata; theileriosis; threonine; valine; Sudan; Resistance; Buparvaquone; Sudan

Drug resistance is one of the emerging and re-emerging epidemics affecting both veterinary and public health sectors. Buparvaquone provides the most satisfactory means in the treatment of bovine tropical theileriosis. However, recently there has been widespread reports of development of resistance o...