Evidence of multiple point mutations in Theileria annulata cytochrome b gene incriminated in buparvaquone treatment failure
Drug resistance is one of the emerging and re-emerging epidemics affecting both veterinary and public health sectors. Buparvaquone provides the most satisfactory means in the treatment of bovine tropical theileriosis. However, recently there has been widespread reports of development of resistance o...
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| Published in | Acta tropica Vol. 191; pp. 128 - 132 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.03.2019
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| Abstract | Drug resistance is one of the emerging and re-emerging epidemics affecting both veterinary and public health sectors. Buparvaquone provides the most satisfactory means in the treatment of bovine tropical theileriosis. However, recently there has been widespread reports of development of resistance of Theileria annulata to buparvaquone. To investigate the situation in Sudan where bovine tropical theileriosis is endemic, fifty blood samples from T. annulata-positive cattle. were used for DNA extraction, PCR and cytochrome b gene nucleotide sequencing. Analysis of the two buparvaquone binding site regions Q01 (130–148) and Q02 (244–266), revealed three non- synonymous mutations at codon 146; alanine (GCT) to threonine (ACT) within the Q01 region across all 50 isolates and the other mutation at codon 129; serine (AGC) to glycine (GGC) in 18 isolates which is very close to the Q01 binding site. However, we documented another mutation at position 227; valine (GTG) to methionine (ATG) close to the close to the Q02 binding site, in three isolates with mutation at codon 129. We concluded that this study has provided evidence of point mutations in the cytochrome b gene of T. annulata that might be associated with buparvaquone treatment failure in Sudan. |
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| AbstractList | Drug resistance is one of the emerging and re-emerging epidemics affecting both veterinary and public health sectors. Buparvaquone provides the most satisfactory means in the treatment of bovine tropical theileriosis. However, recently there has been widespread reports of development of resistance of Theileria annulata to buparvaquone. To investigate the situation in Sudan where bovine tropical theileriosis is endemic, fifty blood samples from T. annulata-positive cattle. were used for DNA extraction, PCR and cytochrome b gene nucleotide sequencing. Analysis of the two buparvaquone binding site regions Q01 (130-148) and Q02 (244-266), revealed three non- synonymous mutations at codon 146; alanine (GCT) to threonine (ACT) within the Q01 region across all 50 isolates and the other mutation at codon 129; serine (AGC) to glycine (GGC) in 18 isolates which is very close to the Q01 binding site. However, we documented another mutation at position 227; valine (GTG) to methionine (ATG) close to the close to the Q02 binding site, in three isolates with mutation at codon 129. We concluded that this study has provided evidence of point mutations in the cytochrome b gene of T. annulata that might be associated with buparvaquone treatment failure in Sudan.Drug resistance is one of the emerging and re-emerging epidemics affecting both veterinary and public health sectors. Buparvaquone provides the most satisfactory means in the treatment of bovine tropical theileriosis. However, recently there has been widespread reports of development of resistance of Theileria annulata to buparvaquone. To investigate the situation in Sudan where bovine tropical theileriosis is endemic, fifty blood samples from T. annulata-positive cattle. were used for DNA extraction, PCR and cytochrome b gene nucleotide sequencing. Analysis of the two buparvaquone binding site regions Q01 (130-148) and Q02 (244-266), revealed three non- synonymous mutations at codon 146; alanine (GCT) to threonine (ACT) within the Q01 region across all 50 isolates and the other mutation at codon 129; serine (AGC) to glycine (GGC) in 18 isolates which is very close to the Q01 binding site. However, we documented another mutation at position 227; valine (GTG) to methionine (ATG) close to the close to the Q02 binding site, in three isolates with mutation at codon 129. We concluded that this study has provided evidence of point mutations in the cytochrome b gene of T. annulata that might be associated with buparvaquone treatment failure in Sudan. Drug resistance is one of the emerging and re-emerging epidemics affecting both veterinary and public health sectors. Buparvaquone provides the most satisfactory means in the treatment of bovine tropical theileriosis. However, recently there has been widespread reports of development of resistance of Theileria annulata to buparvaquone. To investigate the situation in Sudan where bovine tropical theileriosis is endemic, fifty blood samples from T. annulata-positive cattle. were used for DNA extraction, PCR and cytochrome b gene nucleotide sequencing. Analysis of the two buparvaquone binding site regions Q01 (130–148) and Q02 (244–266), revealed three non- synonymous mutations at codon 146; alanine (GCT) to threonine (ACT) within the Q01 region across all 50 isolates and the other mutation at codon 129; serine (AGC) to glycine (GGC) in 18 isolates which is very close to the Q01 binding site. However, we documented another mutation at position 227; valine (GTG) to methionine (ATG) close to the close to the Q02 binding site, in three isolates with mutation at codon 129. We concluded that this study has provided evidence of point mutations in the cytochrome b gene of T. annulata that might be associated with buparvaquone treatment failure in Sudan. Drug resistance is one of the emerging and re-emerging epidemics affecting both veterinary and public health sectors. Buparvaquone provides the most satisfactory means in the treatment of bovine tropical theileriosis. However, recently there has been widespread reports of development of resistance of Theileria annulata to buparvaquone. To investigate the situation in Sudan where bovine tropical theileriosis is endemic, fifty blood samples from T. annulata-positive cattle. were used for DNA extraction, PCR and cytochrome b gene nucleotide sequencing. Analysis of the two buparvaquone binding site regions Q (130-148) and Q (244-266), revealed three non- synonymous mutations at codon 146; alanine (GCT) to threonine (ACT) within the Q region across all 50 isolates and the other mutation at codon 129; serine (AGC) to glycine (GGC) in 18 isolates which is very close to the Q binding site. However, we documented another mutation at position 227; valine (GTG) to methionine (ATG) close to the close to the Q binding site, in three isolates with mutation at codon 129. We concluded that this study has provided evidence of point mutations in the cytochrome b gene of T. annulata that might be associated with buparvaquone treatment failure in Sudan. |
| Author | Nakao, Ryo Amin Alnour, Sondos Salim, Bashir Katakura, Ken Chatanga, Elisha Mosssad, Ehab Abdo Abubaker, Hazem |
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| CitedBy_id | crossref_primary_10_3389_fmicb_2021_759817 crossref_primary_10_1007_s00436_020_06967_y crossref_primary_10_1038_s41598_019_52512_y crossref_primary_10_1007_s00436_023_07916_1 crossref_primary_10_1016_j_ijpddr_2022_08_004 crossref_primary_10_1128_spectrum_02502_22 crossref_primary_10_1016_j_ijpddr_2021_12_003 crossref_primary_10_1016_j_vetpar_2022_109823 crossref_primary_10_1016_j_vprsr_2025_101242 crossref_primary_10_1371_journal_pone_0279925 crossref_primary_10_3389_fvets_2024_1459989 crossref_primary_10_1016_j_actatropica_2023_107103 crossref_primary_10_1038_s41420_019_0180_8 crossref_primary_10_3390_pathogens12020296 crossref_primary_10_1016_j_bioorg_2021_104796 crossref_primary_10_1007_s12639_022_01550_x crossref_primary_10_1016_j_ttbdis_2020_101595 crossref_primary_10_1016_j_vetpar_2024_110183 crossref_primary_10_1016_j_ijpddr_2019_11_001 crossref_primary_10_1016_j_vetpar_2024_110321 crossref_primary_10_1111_tbed_13359 crossref_primary_10_1371_journal_pone_0299002 crossref_primary_10_1111_tbed_13312 crossref_primary_10_1007_s11030_019_10018_9 crossref_primary_10_3389_fimmu_2024_1400308 crossref_primary_10_1007_s00436_021_07158_z crossref_primary_10_1007_s11756_021_00966_9 crossref_primary_10_3390_pathogens9050334 crossref_primary_10_3906_vet_2002_20 crossref_primary_10_1038_s42003_022_03981_x |
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| SubjectTerms | alanine binding sites blood sampling Buparvaquone cattle cytochrome b disease outbreaks DNA drug resistance genes glycine (amino acid) methionine point mutation polymerase chain reaction Resistance serine Sudan Theileria annulata theileriosis threonine valine |
| Title | Evidence of multiple point mutations in Theileria annulata cytochrome b gene incriminated in buparvaquone treatment failure |
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