Visualizing central effects of S-adenosyl-L-methionine (SAMe), a natural molecule with antidepressant properties, by pharmaco-EEG mapping

• Published in: The international journal of neuropsychopharmacology Vol. 5; no. 3; pp. 199 - 215
• Main Authors: Saletu-Zyhlarz, Gerda M., Anderer, Peter, Linzmayer, Leopold, Semlitsch, Heribert V., Assandri, Alessandro, Prause, Wolfgang, Hassan Abu-Bakr, Manal, Lindeck-Pozza, Elisabeth, Saletu, Bernd
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.09.2002; Oxford University Press
• Subjects: Adult; Alpha Rhythm - drug effects; Antidepressants; Antidepressive Agents - pharmacology; Arousal - drug effects; Attention - drug effects; Beta Rhythm - drug effects; Blood Pressure - drug effects; Brain Mapping; Cross-Over Studies; Double-Blind Method; Drug dosages; Electroencephalography; Electroencephalography - drug effects; Female; Flicker Fusion - drug effects; Heart Rate - drug effects; Humans; Male; Psychometrics; Quantitative psychology; S-Adenosylmethionine - pharmacology; Time Factors; Ademetionine; pharmaco-EEG mapping; psychotropic effects; psychometry; encephalotropic effects; nutraceutical and pharmaceutical substance

In a double-blind, placebo-controlled, cross-over study, the central effects of the natural molecule S-adenosyl-L-methionine (SAMe), or ademetionine (ADE), used in low doses as a nutraceutical and in higher doses as a pharmaceutical, were investigated by means of EEG mapping and psychometry. Ten you...