Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

• Published in: Science (American Association for the Advancement of Science) Vol. 341; no. 6152; pp. 1359 - 1365
• Main Authors: Seder, Robert A., Chang, Lee-Jah, Enama, Mary E., Zephir, Kathryn L., Sarwar, Uzma N., Gordon, Ingelise J., Holman, LaSonji A., James, Eric R., Billingsley, Peter F., Gunasekera, Anusha, Richman, Adam, Chakravarty, Sumana, Manoj, Anita, Velmurugan, Soundarapandian, Li, MingLin, Ruben, Adam J., Li, Tao, Eappen, Abraham G., Stafford, Richard E., Plummer, Sarah H., Hendel, Cynthia S., Novik, Laura, Costner, Pamela J. M., Mendoza, Floreliz H., Saunders, Jamie G., Nason, Martha C., Richardson, Jason H., Murphy, Jittawadee, Davidson, Silas A., Richie, Thomas L., Sedegah, Martha, Sutamihardja, Awalludin, Fahle, Gary A., Lyke, Kirsten E., Laurens, Matthew B., Roederer, Mario, Tewari, Kavita, Epstein, Judith E., Sim, B. Kim Lee, Ledgerwood, Julie E., Graham, Barney S., Hoffman, Stephen L.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 20.09.2013; The American Association for the Advancement of Science
• Subjects: Administration, Intravenous; Adult; Animals; Antibodies; Antigens; Aquatic insects; Attenuation; Biological and medical sciences; cell-mediated immunity; Cellular; clinical trials; Correlation; Cytokines - immunology; Dosage; Female; Human protozoal diseases; Humans; Immune response; Immune system; Immunity, Cellular; Immunization; Infectious diseases; Insect bites; intravenous injection; Intravenous injections; Malaria; Malaria Vaccines - administration & dosage; Malaria Vaccines - adverse effects; Malaria Vaccines - immunology; Malaria, Falciparum - prevention & control; Male; Medical research; Medical sciences; Mice; Monoclonal antibodies; Mosquitoes; Parasites; Parasitic diseases; people; Plasmodium falciparum; Plasmodium falciparum - immunology; Protozoal diseases; RESEARCH ARTICLE; Sporozoites; Sporozoites - immunology; T lymphocytes; T-Lymphocytes - immunology; Vaccination; Vaccination - adverse effects; Vaccination - methods; Vaccines; Vector-borne diseases; Human; Protozoa; Apicomplexa; Protozoal disease; Malaria; Vaccination; Sporozoit; Vaccine; Parasitosis; Active immunization; Infection; Prevention; Immunoprophylaxis; Plasmodium falciparum; Attenuated strain

Consistent high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites. We report that the PfSPZ Vaccine—composed of attenuated, aseptic, purified, cryopreserved PfSPZ—was safe and well tolerated...