SARS–CoV-2 infection of the placenta

• Published in: The Journal of clinical investigation Vol. 130; no. 9; pp. 4947 - 4953
• Main Authors: Hosier, Hillary, Farhadian, Shelli F., Morotti, Raffaella A., Deshmukh, Uma, Lu-Culligan, Alice, Campbell, Katherine H., Yasumoto, Yuki, Vogels, Chantal B.F., Casanovas-Massana, Arnau, Vijayakumar, Pavithra, Geng, Bertie, Odio, Camila D., Fournier, John, Brito, Anderson F., Fauver, Joseph R., Liu, Feimei, Alpert, Tara, Tal, Reshef, Szigeti-Buck, Klara, Perincheri, Sudhir, Larsen, Christopher, Gariepy, Aileen M., Aguilar, Gabriela, Fardelmann, Kristen L., Harigopal, Malini, Taylor, Hugh S., Pettker, Christian M., Wyllie, Anne L., Cruz, Charles Dela, Ring, Aaron M., Grubaugh, Nathan D., Ko, Albert I., Horvath, Tamas L., Iwasaki, Akiko, Reddy, Uma M., Lipkind, Heather S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.09.2020
• Subjects: Abortion, Therapeutic; Abruptio Placentae - etiology; Abruptio Placentae - pathology; Abruptio Placentae - virology; Adult; Analysis; Betacoronavirus - genetics; Betacoronavirus - isolation & purification; Betacoronavirus - pathogenicity; Clinical Medicine; Coronavirus Infections - complications; Coronavirus Infections - pathology; Coronavirus Infections - virology; Coronaviruses; COVID-19; Female; Health aspects; Humans; Microscopy, Electron, Transmission; Neonatology; Pandemics; Phylogeny; Placenta - pathology; Placenta - virology; Pneumonia, Viral - complications; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; Pre-Eclampsia - etiology; Pre-Eclampsia - pathology; Pre-Eclampsia - virology; Pregnancy; Pregnancy Complications, Infectious - etiology; Pregnancy Complications, Infectious - pathology; Pregnancy Complications, Infectious - virology; Pregnancy Trimester, Second; Pregnant women; RNA, Viral - genetics; RNA, Viral - isolation & purification; SARS-CoV-2; Severe acute respiratory syndrome; Tranexamic acid; Venture capital companies; Viral Load; Connecticut; COVID-19; Molecular pathology; Reproductive Biology

BACKGROUNDThe effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.METHODSWe analyzed the placenta for the presence of seve...