Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 9; pp. 2425 - 2430
• Main Authors: Kazmin, Dmitri, Nakaya, Helder I., Lee, Eva K., Johnson, Matthew J., van der Most, Robbert, van den Berg, Robert A., Ballou, W. Ripley, Jongert, Erik, Wille-Reece, Ulrike, Ockenhouse, Christian, Aderem, Alan, Zak, Daniel E., Sadoff, Jerald, Hendriks, Jenny, Wrammert, Jens, Ahmed, Rafi, Pulendran, Bali
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 28.02.2017
• Subjects: Adaptive Immunity - drug effects; Adenoviridae; Adenoviridae - genetics; Adenoviridae - immunology; Antibodies, Protozoan - biosynthesis; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biological Sciences; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dendritic Cells - metabolism; Gene Expression Profiling; Gene Expression Regulation; Genetic Vectors - chemistry; Genetic Vectors - immunology; Humans; Immunity (Disease); Immunity, Innate - drug effects; Immunization; Immunization, Secondary - methods; Immunogenicity, Vaccine; Killer Cells, Natural - drug effects; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Malaria; Malaria Vaccines - administration & dosage; Malaria, Falciparum - immunology; Malaria, Falciparum - parasitology; Malaria, Falciparum - prevention & control; Parasitic protozoa; Plasmodium falciparum; Plasmodium falciparum - immunology; Plasmodium falciparum - pathogenicity; Proteins; Protozoan Proteins - administration & dosage; Protozoan Proteins - genetics; Protozoan Proteins - immunology; Systematic biology; Systems analysis; Vaccination - methods; Vaccines; Vaccines, Synthetic - administration & dosage; Vector-borne diseases; systems biology; systems vaccinology; vaccine; immune; malaria

RTS,S is an advanced malaria vaccine candidate and confers significant protection against Plasmodium falciparum infection in humans. Little is known about the molecular mechanisms driving vaccine immunity. Here, we applied a systems biology approach to study immune responses in subjects receiving th...