Unravelling Glucan Recognition Systems by Glycome Microarrays Using the Designer Approach and Mass Spectrometry[S]

• Published in: Molecular & cellular proteomics Vol. 14; no. 4; pp. 974 - 988
• Main Authors: Palma, Angelina S., Liu, Yan, Zhang, Hongtao, Zhang, Yibing, McCleary, Barry V., Yu, Guangli, Huang, Qilin, Guidolin, Leticia S., Ciocchini, Andres E., Torosantucci, Antonella, Wang, Denong, Carvalho, Ana Luísa, Fontes, CarlosM.G.A., Mulloy, Barbara, Childs, Robert A., Feizi, Ten, Chai, Wengang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015; The American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Antibodies - metabolism; Carbohydrate Sequence; Cell Adhesion Molecules - metabolism; Glucans - metabolism; Immune System - metabolism; Lectins, C-Type - metabolism; Ligands; Mice; Oligosaccharides - chemistry; Oligosaccharides - metabolism; Protein Array Analysis - methods; Protein Binding; Proteome - metabolism; Receptors, Cell Surface - metabolism; Reproducibility of Results; Signal Transduction; Spectrometry, Mass, Electrospray Ionization - methods; Vaccines - immunology

Glucans are polymers of d-glucose with differing linkages in linear or branched sequences. They are constituents of microbial and plant cell-walls and involved in important bio-recognition processes, including immunomodulation, anticancer activities, pathogen virulence, and plant cell-wall biodegrad...