Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 52; pp. 15024 - 15029
• Main Authors: Carr, Michael I., Roderick, Justine E., Zhang, Hong, Woda, Bruce A., Kelliher, Michelle A., Jones, Stephen N.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.12.2016
• Subjects: Apoptosis; Biological Sciences; Bone marrow; Cells; Deoxyribonucleic acid; DNA; DNA damage; Ionizing radiation; Mutation; Phosphorylation; Rodents; Tumors; Mdm2; c-Abl; tumorigenesis; DNA damage; p53

The p53 tumor suppressor acts as a guardian of the genome by preventing the propagation of DNA damage-induced breaks and mutations to subsequent generations of cells. We have previously shown that phosphorylation of the Mdm2 oncoprotein at Ser394 by the ATM kinase is required for robust p53 stabiliz...