Evaluation of marker gene expression as a potential predictive marker of leukopenic toxicity for inactivated influenza vaccines

• Published in: Biologicals Vol. 50; pp. 100 - 108
• Main Authors: Sasaki, Eita, Momose, Haruka, Hiradate, Yuki, Furuhata, Keiko, Takai, Mamiko, Kamachi, Kazunari, Asanuma, Hideki, Ishii, Ken J., Mizukami, Takuo, Hamaguchi, Isao
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2017
• Subjects: biomarkers; gene expression; genes; genetic markers; hemagglutinins; influenza; Influenza vaccine; influenza vaccines; leukocytes; Leukopenic toxicity test; Marker gene; mice; prediction; regression analysis; Safety test; toxicity; toxicity testing; ATT; LTT; JMR; SA; RE; WBC; Safety test; QGP; HAv; WPV; Influenza vaccine; Leukopenic toxicity test; Marker gene

The leukopenic toxicity test (LTT) is used to evaluate the safety and lot-to-lot consistency of influenza hemagglutinin split vaccine (HAv) and is included in the Japanese Minimum Requirements for Biological Products. LTT assesses the reduced leukocyte levels in murine peripheral blood after HAv adm...