BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion?
Summary We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year–old man with goiter. The entire gland was examined; in 1 section, the cells of 1 solid cell nest were in close contact with a follicular variant of papillary microcarcinoma. A second fo...
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| Published in | Human pathology Vol. 40; no. 7; pp. 1029 - 1035 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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New York, NY
Elsevier Inc
01.07.2009
Elsevier Elsevier Limited |
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| Abstract | Summary We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year–old man with goiter. The entire gland was examined; in 1 section, the cells of 1 solid cell nest were in close contact with a follicular variant of papillary microcarcinoma. A second follicular variant of papillary microcarcinoma, 1 follicular adenoma, hyperplastic nodules, and some lymphoid aggregates were also found. Scattered p63-positive cells were found in the second papillary microcarcinoma. After microdissection, the same BRAFV600E mutation was found both in a pool of 5 solid cell nests and in the adjacent papillary microcarcinoma. BRAFV600E mutation and the previously unreported BRAFG593D mutation along with p.G606G silent change were found in the second papillary microcarcinoma, but no mutations were detected in the follicular adenoma or in the 2 other pools of solid cell nests screened for BRAF gene mutations. These findings support a histogenetic link between the main cells of solid cell nests and papillary thyroid carcinoma, and suggest solid cell nest hyperplasia as a precursor lesion of papillary thyroid carcinoma. |
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| AbstractList | We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year-old man with goiter. The entire gland was examined; in 1 section, the cells of 1 solid cell nest were in close contact with a follicular variant of papillary microcarcinoma. A second follicular variant of papillary microcarcinoma, 1 follicular adenoma, hyperplastic nodules, and some lymphoid aggregates were also found. Scattered p63-positive cells were found in the second papillary microcarcinoma. After microdissection, the same BRAF(V600E) mutation was found both in a pool of 5 solid cell nests and in the adjacent papillary microcarcinoma. BRAF(V600E) mutation and the previously unreported BRAF(G593D) mutation along with p.G606G silent change were found in the second papillary microcarcinoma, but no mutations were detected in the follicular adenoma or in the 2 other pools of solid cell nests screened for BRAF gene mutations. These findings support a histogenetic link between the main cells of solid cell nests and papillary thyroid carcinoma, and suggest solid cell nest hyperplasia as a precursor lesion of papillary thyroid carcinoma. Summary We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year–old man with goiter. The entire gland was examined; in 1 section, the cells of 1 solid cell nest were in close contact with a follicular variant of papillary microcarcinoma. A second follicular variant of papillary microcarcinoma, 1 follicular adenoma, hyperplastic nodules, and some lymphoid aggregates were also found. Scattered p63-positive cells were found in the second papillary microcarcinoma. After microdissection, the same BRAFV600E mutation was found both in a pool of 5 solid cell nests and in the adjacent papillary microcarcinoma. BRAFV600E mutation and the previously unreported BRAFG593D mutation along with p.G606G silent change were found in the second papillary microcarcinoma, but no mutations were detected in the follicular adenoma or in the 2 other pools of solid cell nests screened for BRAF gene mutations. These findings support a histogenetic link between the main cells of solid cell nests and papillary thyroid carcinoma, and suggest solid cell nest hyperplasia as a precursor lesion of papillary thyroid carcinoma. We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year-old man with goiter. The entire gland was examined; in 1 section, the cells of 1 solid cell nest were in close contact with a follicular variant of papillary microcarcinoma. A second follicular variant of papillary microcarcinoma, 1 follicular adenoma, hyperplastic nodules, and some lymphoid aggregates were also found. Scattered p63-positive cells were found in the second papillary microcarcinoma. After microdissection, the same BRAFV600E mutation was found both in a pool of 5 solid cell nests and in the adjacent papillary microcarcinoma. BRAFV600E mutation and the previously unreported BRAFG593D mutation along with p.G606G silent change were found in the second papillary microcarcinoma, but no mutations were detected in the follicular adenoma or in the 2 other pools of solid cell nests screened for BRAF gene mutations. These findings support a histogenetic link between the main cells of solid cell nests and papillary thyroid carcinoma, and suggest solid cell nest hyperplasia as a precursor lesion of papillary thyroid carcinoma. We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year–old man with goiter. The entire gland was examined; in 1 section, the cells of 1 solid cell nest were in close contact with a follicular variant of papillary microcarcinoma. A second follicular variant of papillary microcarcinoma, 1 follicular adenoma, hyperplastic nodules, and some lymphoid aggregates were also found. Scattered p63-positive cells were found in the second papillary microcarcinoma. After microdissection, the same BRAF V600E mutation was found both in a pool of 5 solid cell nests and in the adjacent papillary microcarcinoma. BRAF V600E mutation and the previously unreported BRAF G593D mutation along with p.G606G silent change were found in the second papillary microcarcinoma, but no mutations were detected in the follicular adenoma or in the 2 other pools of solid cell nests screened for BRAF gene mutations. These findings support a histogenetic link between the main cells of solid cell nests and papillary thyroid carcinoma, and suggest solid cell nest hyperplasia as a precursor lesion of papillary thyroid carcinoma. |
| Author | Abdulkader, Ihab, MD PhD Forteza, Jerónimo, MD, PhD Cameselle-Teijeiro, José, MD, PhD Sobrinho-Simões, Manuel, MD, PhD Pérez-Becerra, Raquel, BSc Vázquez-Boquete, Angel, BSc Alberte-Lista, Lara, MD Ruiz-Ponte, Clara, PhD |
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| Keywords | BRAF gene Papillary carcinoma Microcarcinoma Solid cell nests Thyroid Endocrinopathy Endocrine gland Hyperplasia Thyroid diseases Thyroid gland Malignant tumor Precursor Anatomic pathology BRAF Gene Association C-Onc gene Genetics Lesion Mutation Cell Papillary thyroid carcinoma Protooncogene Cancer |
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| Snippet | Summary We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year–old man with goiter. The entire gland was... We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year–old man with goiter. The entire gland was examined;... We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year-old man with goiter. The entire gland was examined;... |
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| SubjectTerms | Biological and medical sciences BRAF gene Carcinoma, Papillary - genetics Carcinoma, Papillary - pathology Cell Transformation, Neoplastic - genetics Endocrinopathies Genetic testing Goiter - etiology Goiter - pathology Humans Hypotheses Investigative techniques, diagnostic techniques (general aspects) Lasers Male Malignant tumors Medical sciences Microcarcinoma Middle Aged Mutation Papillary carcinoma Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins B-raf - genetics Solid cell nests Stem cells Therapy Thyroid Thyroid cancer Thyroid gland Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases) Tumors |
| Title | BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? |
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