Repair of Cranial Defects in Rabbits with 3D-Printed Hydroxyapatite/Polylactic Acid Composites

• Published in: BioMed research international Vol. 2022; no. 1; p. 7562291
• Main Authors: Fan, Guofeng, Yang, Liu, Liu, Dong, Wang, Yongxin, Ji, Wenyu, Tukebai, Qin, Hu, Wang, Zengliang
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2022; John Wiley & Sons, Inc
• Subjects: 3-D printers; 3D printing; Animals; Biocompatibility; Bone growth; Bone marrow; Bone regeneration; Bone surgery; Bones; Care and treatment; Composite materials; Cranium; Defects; Design and construction; Diameters; Drilling; Durapatite - pharmacology; Equipment and supplies; Experiments; Feasibility studies; Hardness; Hardness tests; Humans; Hydroxyapatite; Materials research; Medical research; Methods; Microhardness; Polyesters - pharmacology; Polylactic acid; Powder; Powders; Printing, Three-Dimensional; Rabbits; Regeneration; Regeneration (physiology); Skin; Skull; Skull - surgery; Statistical analysis; Surgery; Surgery, Plastic; Testing; Thermoplastics; Three dimensional composites; Three dimensional printing; Tissue Engineering; Tissue Scaffolds; New Zealand; United States > US

Objective. The safety and efficacy of three-dimensional- (3D-) printed hydroxyapatite/polylactic acid (HA-PLA) composites in repairing cranial defects were evaluated in a rabbit experimental model. Methods. Twelve New Zealand rabbits were selected as experimental subjects. Two holes (A and B), each...