Acute inflammation plays a limited role in the regulation of adipose tissue COL1A1 protein abundance

• Published in: The Journal of nutritional biochemistry Vol. 23; no. 6; pp. 567 - 572
• Main Authors: Adapala, Venkata J, Adedokun, Sunday A, Considine, Robert V, Ajuwon, Kolapo M
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2012; Elsevier
• Subjects: Adipose; adipose tissue; Adult; Animals; Biglycan; Biglycan - genetics; Biglycan - metabolism; Biological and medical sciences; Blotting, Western; collagen; Collagen Type I; Collagen Type I - genetics; Collagen Type I - metabolism; complications; Diet, High-Fat; Energy Intake; etiology; Extracellular; extracellular matrix; Extracellular Matrix Proteins; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; gene expression; genes; genetics; high fat diet; Humans; Inflammation; Inflammation - etiology; Inflammation - pathology; Male; Matrix; Matrix Metalloproteinase 2; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 3; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 3 - metabolism; Matrix Metalloproteinase 9; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; messenger RNA; metabolism; Metalloproteases; metalloproteinases; Mice; Mice, Inbred C57BL; Middle Aged; Obesity; Obesity - complications; Obesity - pathology; pathology; protein metabolism; RNA, Messenger; Subcutaneous Fat; Subcutaneous Fat - metabolism; Subcutaneous Fat - pathology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Western blotting; Young Adult; Metalloproteases; Obesity; Adipose; Inflammation; Matrix; Extracellular; Adipose tissue; Enzyme; Acute; Nutrition disorder; Metalloendopeptidases; Protein; Peptidases; Vertebrata; Regulation(control); Mammalia; Hydrolases; Limit; Nutritional status

Obesity is an inflammatory condition that is also associated with increased extracellular matrix (ECM) gene expression. However, a direct link between adipose tissue inflammation and ECM gene expression has not been established. Therefore, we determined the effect of chronic inflammation induced by...