Identification of salivary metabolomic biomarkers for oral cancer screening
The objective of this study was to explore salivary metabolite biomarkers by profiling both saliva and tumor tissue samples for oral cancer screening. Paired tumor and control tissues were obtained from oral cancer patients and whole unstimulated saliva samples were collected from patients and healt...
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| Published in | Scientific reports Vol. 6; no. 1; p. 31520 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
19.08.2016
Nature Publishing Group |
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| Abstract | The objective of this study was to explore salivary metabolite biomarkers by profiling both saliva and tumor tissue samples for oral cancer screening. Paired tumor and control tissues were obtained from oral cancer patients and whole unstimulated saliva samples were collected from patients and healthy controls. The comprehensive metabolomic analysis for profiling hydrophilic metabolites was conducted using capillary electrophoresis time-of-flight mass spectrometry. In total, 85 and 45 metabolites showed significant differences between tumor and matched control samples and between salivary samples from oral cancer and controls, respectively (
P
< 0.05 correlated by false discovery rate); 17 metabolites showed consistent differences in both saliva and tissue-based comparisons. Of these, a combination of only two biomarkers yielded a high area under receiver operating characteristic curves (0.827; 95% confidence interval, 0.726–0.928,
P
< 0.0001) for discriminating oral cancers from controls. Various validation tests confirmed its high generalization ability. The demonstrated approach, integrating both saliva and tumor tissue metabolomics, helps eliminate pseudo-molecules that are coincidentally different between oral cancers and controls. These combined salivary metabolites could be the basis of a clinically feasible method of non-invasive oral cancer screening. |
|---|---|
| AbstractList | The objective of this study was to explore salivary metabolite biomarkers by profiling both saliva and tumor tissue samples for oral cancer screening. Paired tumor and control tissues were obtained from oral cancer patients and whole unstimulated saliva samples were collected from patients and healthy controls. The comprehensive metabolomic analysis for profiling hydrophilic metabolites was conducted using capillary electrophoresis time-of-flight mass spectrometry. In total, 85 and 45 metabolites showed significant differences between tumor and matched control samples and between salivary samples from oral cancer and controls, respectively (
P
< 0.05 correlated by false discovery rate); 17 metabolites showed consistent differences in both saliva and tissue-based comparisons. Of these, a combination of only two biomarkers yielded a high area under receiver operating characteristic curves (0.827; 95% confidence interval, 0.726–0.928,
P
< 0.0001) for discriminating oral cancers from controls. Various validation tests confirmed its high generalization ability. The demonstrated approach, integrating both saliva and tumor tissue metabolomics, helps eliminate pseudo-molecules that are coincidentally different between oral cancers and controls. These combined salivary metabolites could be the basis of a clinically feasible method of non-invasive oral cancer screening. The objective of this study was to explore salivary metabolite biomarkers by profiling both saliva and tumor tissue samples for oral cancer screening. Paired tumor and control tissues were obtained from oral cancer patients and whole unstimulated saliva samples were collected from patients and healthy controls. The comprehensive metabolomic analysis for profiling hydrophilic metabolites was conducted using capillary electrophoresis time-of-flight mass spectrometry. In total, 85 and 45 metabolites showed significant differences between tumor and matched control samples, and between salivary samples from oral cancer and controls, respectively (P < 0.05 correlated by false discovery rate); 17 metabolites showed consistent differences in both saliva and tissue-based comparisons. Of these, a combination of only two biomarkers yielded a high area under receiver operating characteristic curves (0.827; 95% confidence interval, 0.726-0.928, P < 0.0001) for discriminating oral cancers from controls. Various validation tests confirmed its high generalization ability. The demonstrated approach, integrating both saliva and tumor tissue metabolomics, helps eliminate pseudo-molecules that are coincidentally different between oral cancers and controls. These combined salivary metabolites could be the basis of a clinically feasible method of non-invasive oral cancer screening. The objective of this study was to explore salivary metabolite biomarkers by profiling both saliva and tumor tissue samples for oral cancer screening. Paired tumor and control tissues were obtained from oral cancer patients and whole unstimulated saliva samples were collected from patients and healthy controls. The comprehensive metabolomic analysis for profiling hydrophilic metabolites was conducted using capillary electrophoresis time-of-flight mass spectrometry. In total, 85 and 45 metabolites showed significant differences between tumor and matched control samples, and between salivary samples from oral cancer and controls, respectively (P < 0.05 correlated by false discovery rate); 17 metabolites showed consistent differences in both saliva and tissue-based comparisons. Of these, a combination of only two biomarkers yielded a high area under receiver operating characteristic curves (0.827; 95% confidence interval, 0.726-0.928, P < 0.0001) for discriminating oral cancers from controls. Various validation tests confirmed its high generalization ability. The demonstrated approach, integrating both saliva and tumor tissue metabolomics, helps eliminate pseudo-molecules that are coincidentally different between oral cancers and controls. These combined salivary metabolites could be the basis of a clinically feasible method of non-invasive oral cancer screening.The objective of this study was to explore salivary metabolite biomarkers by profiling both saliva and tumor tissue samples for oral cancer screening. Paired tumor and control tissues were obtained from oral cancer patients and whole unstimulated saliva samples were collected from patients and healthy controls. The comprehensive metabolomic analysis for profiling hydrophilic metabolites was conducted using capillary electrophoresis time-of-flight mass spectrometry. In total, 85 and 45 metabolites showed significant differences between tumor and matched control samples, and between salivary samples from oral cancer and controls, respectively (P < 0.05 correlated by false discovery rate); 17 metabolites showed consistent differences in both saliva and tissue-based comparisons. Of these, a combination of only two biomarkers yielded a high area under receiver operating characteristic curves (0.827; 95% confidence interval, 0.726-0.928, P < 0.0001) for discriminating oral cancers from controls. Various validation tests confirmed its high generalization ability. The demonstrated approach, integrating both saliva and tumor tissue metabolomics, helps eliminate pseudo-molecules that are coincidentally different between oral cancers and controls. These combined salivary metabolites could be the basis of a clinically feasible method of non-invasive oral cancer screening. |
| ArticleNumber | 31520 |
| Author | Soga, Tomoyoshi Kitabatake, Kenichiro Ota, Sana Hiwatari, Kana Kaneko, Miku Tomita, Masaru Nakamura, Marina Iino, Mitsuyoshi Sugimoto, Masahiro Sugano, Ayako Enomoto, Ayame Ishikawa, Shigeo |
| Author_xml | – sequence: 1 givenname: Shigeo surname: Ishikawa fullname: Ishikawa, Shigeo organization: Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University – sequence: 2 givenname: Masahiro surname: Sugimoto fullname: Sugimoto, Masahiro organization: Institute for Advanced Biosciences, Keio University, Department of Oral Science, Division of Orthodontics, Graduate School of Dentistry, Kanagawa Dental University – sequence: 3 givenname: Kenichiro surname: Kitabatake fullname: Kitabatake, Kenichiro organization: Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University – sequence: 4 givenname: Ayako surname: Sugano fullname: Sugano, Ayako organization: Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University – sequence: 5 givenname: Marina surname: Nakamura fullname: Nakamura, Marina organization: Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University – sequence: 6 givenname: Miku surname: Kaneko fullname: Kaneko, Miku organization: Institute for Advanced Biosciences, Keio University – sequence: 7 givenname: Sana surname: Ota fullname: Ota, Sana organization: Institute for Advanced Biosciences, Keio University – sequence: 8 givenname: Kana surname: Hiwatari fullname: Hiwatari, Kana organization: Institute for Advanced Biosciences, Keio University – sequence: 9 givenname: Ayame surname: Enomoto fullname: Enomoto, Ayame organization: Institute for Advanced Biosciences, Keio University – sequence: 10 givenname: Tomoyoshi surname: Soga fullname: Soga, Tomoyoshi organization: Institute for Advanced Biosciences, Keio University – sequence: 11 givenname: Masaru surname: Tomita fullname: Tomita, Masaru organization: Institute for Advanced Biosciences, Keio University – sequence: 12 givenname: Mitsuyoshi surname: Iino fullname: Iino, Mitsuyoshi organization: Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27539254$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1593/neo.81396 10.1016/j.cca.2015.10.032 10.1158/1078-0432.CCR-09-0736 10.1016/j.oraloncology.2007.06.007 10.1002/lary.21721 10.1288/00005537-198902000-00001 10.1001/archotol.128.3.313 10.1016/j.febslet.2009.03.038 10.1007/s11306-009-0178-y 10.1074/jbc.M601876200 10.1021/ac402526c 10.1158/0008-5472.CAN-08-4806 10.3322/caac.20006 10.1096/fasebj.10.4.8647346 10.1002/ijc.25881 10.1016/j.cca.2013.10.004 10.1097/00001622-199505000-00007 10.1186/1746-160X-9-34 10.1158/1055-9965.EPI-11-1093 10.1245/s10434-012-2392-5 10.1016/j.ajoms.2013.04.008 10.1053/j.gastro.2009.11.010 10.1056/NEJM199301213280306 10.1158/1078-0432.CCR-07-5037 10.1016/S0076-6879(06)11009-5 10.1021/pr800979e 10.1080/10731190902913759 10.1371/journal.pone.0103265 10.1158/1078-0432.CCR-04-1167 10.1016/j.aca.2013.06.044 10.1159/000030045 10.1021/ac9020598 10.1007/s11306-012-0464-y 10.1177/172460081002500206 10.1038/sj.ebd.6401094 10.3322/caac.21332 10.14219/jada.archive.2010.0223 10.1158/1940-6207.CAPR-10-0173 10.1111/j.1749-6632.1993.tb18343.x 10.1111/j.1600-0528.2010.00579.x 10.1902/jop.1972.43.1.38 10.1016/j.oooo.2014.04.003 10.3390/ijms11093106 10.1080/10618600.1996.10474713 10.1158/1078-0432.CCR-12-3505 10.1158/1078-0432.CCR-15-1761 10.4172/2153-0769.1000128 10.1371/journal.pone.0062375 |
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| References | Ihaka, Gentleman (CR35) 1996; 5 Sun, He, Ping, Zhang (CR14) 2009; 37 Vokes, Weichselbaum, Lippman, Hong (CR2) 1993; 328 Ishikawa (CR7) 2013; 9 Elashoff (CR23) 2012; 21 Yan (CR29) 2008; 44 Wei (CR24) 2011; 129 Hu (CR47) 2008; 14 Ogawa, Washio, Takahashi, Echigo, Takahashi (CR31) 2014; 118 Sugimoto, Wong, Hirayama, Soga, Tomita (CR25) 2010; 6 Li (CR20) 2004; 10 Lin (CR44) 2011; 121 Navazesh (CR48) 1993; 694 Tsutsui (CR52) 2013; 85 Soga (CR33) 2006; 281 O’Leary, Drake, Naylor (CR50) 1972; 43 Matse (CR30) 2013; 19 Sugimoto (CR34) 2013; 9 Saeed (CR36) 2006; 411 Arellano-Garcia (CR13) 2010; 11 Sidransky (CR3) 1995; 7 CR42 Levin (CR40) 2000; 6 Huang (CR19) 2012; 19 Feng, Li, Li, Han, Xing (CR18) 2010; 25 Bijian (CR15) 2009; 8 Bertram, Eggers, Eller (CR27) 2009; 81 Obeid, Herrmann (CR39) 2009; 583 Jemal (CR1) 2009; 59 Tiziani, Lopes, Gunther (CR16) 2009; 11 Zhang (CR49) 2010; 138 Ishikawa (CR6) 2014; 26 Carvalho (CR5) 2002; 128 Park (CR22) 2009; 15 Torre (CR17) 1998; 19 Santini (CR53) 2003; 23 Chen (CR46) 2014; 9 Hirayama (CR51) 2009; 69 Eibling, Johnson, Wagner, Su (CR45) 1989; 99 Liu (CR41) 2013; 791 Chiang (CR38) 1996; 10 Siegel, Miller, Jemal (CR8) 2016; 66 Spivakovsky, Gerber (CR11) 2015; 16 CR26 Wang, Gao, Wang, Duan (CR28) 2014; 427 Takayama (CR43) 2016; 452 Balevi (CR12) 2011; 39 Rethman (CR10) 2010; 141 CR21 Lingen (CR4) 2010; 3 Koh (CR32) 2013; 27 Epstein, Zhang, Rosin (CR9) 2002; 68 Buczko, Zalewska, Szarmach (CR37) 2015; 66 T Takayama (BFsrep31520_CR43) 2016; 452 EE Vokes (BFsrep31520_CR2) 1993; 328 K Bijian (BFsrep31520_CR15) 2009; 8 Q Wang (BFsrep31520_CR28) 2014; 427 TJ O’Leary (BFsrep31520_CR50) 1972; 43 D Sidransky (BFsrep31520_CR3) 1995; 7 T Koh (BFsrep31520_CR32) 2013; 27 AI Saeed (BFsrep31520_CR36) 2006; 411 D Santini (BFsrep31520_CR53) 2003; 23 S Spivakovsky (BFsrep31520_CR11) 2015; 16 ME Arellano-Garcia (BFsrep31520_CR13) 2010; 11 M Navazesh (BFsrep31520_CR48) 1993; 694 M Sugimoto (BFsrep31520_CR25) 2010; 6 R Liu (BFsrep31520_CR41) 2013; 791 A Jemal (BFsrep31520_CR1) 2009; 59 MW Lingen (BFsrep31520_CR4) 2010; 3 BFsrep31520_CR26 BFsrep31520_CR21 MP Rethman (BFsrep31520_CR10) 2010; 141 DE Eibling (BFsrep31520_CR45) 1989; 99 L Zhang (BFsrep31520_CR49) 2010; 138 VA Levin (BFsrep31520_CR40) 2000; 6 WH Lin (BFsrep31520_CR44) 2011; 121 Y Li (BFsrep31520_CR20) 2004; 10 AL Carvalho (BFsrep31520_CR5) 2002; 128 SK Yan (BFsrep31520_CR29) 2008; 44 RL Siegel (BFsrep31520_CR8) 2016; 66 HC Bertram (BFsrep31520_CR27) 2009; 81 G Sun (BFsrep31520_CR14) 2009; 37 GC Torre (BFsrep31520_CR17) 1998; 19 M Sugimoto (BFsrep31520_CR34) 2013; 9 S Hu (BFsrep31520_CR47) 2008; 14 T Ogawa (BFsrep31520_CR31) 2014; 118 SF Huang (BFsrep31520_CR19) 2012; 19 S Ishikawa (BFsrep31520_CR6) 2014; 26 JH Matse (BFsrep31520_CR30) 2013; 19 H Tsutsui (BFsrep31520_CR52) 2013; 85 T Soga (BFsrep31520_CR33) 2006; 281 IH Chen (BFsrep31520_CR46) 2014; 9 P Buczko (BFsrep31520_CR37) 2015; 66 A Hirayama (BFsrep31520_CR51) 2009; 69 PK Chiang (BFsrep31520_CR38) 1996; 10 NJ Park (BFsrep31520_CR22) 2009; 15 JB Epstein (BFsrep31520_CR9) 2002; 68 BFsrep31520_CR42 B Balevi (BFsrep31520_CR12) 2011; 39 XY Feng (BFsrep31520_CR18) 2010; 25 R Obeid (BFsrep31520_CR39) 2009; 583 R Ihaka (BFsrep31520_CR35) 1996; 5 S Ishikawa (BFsrep31520_CR7) 2013; 9 J Wei (BFsrep31520_CR24) 2011; 129 D Elashoff (BFsrep31520_CR23) 2012; 21 S Tiziani (BFsrep31520_CR16) 2009; 11 |
| References_xml | – volume: 11 start-page: 269 year: 2009 end-page: 276 ident: CR16 article-title: Early stage diagnosis of oral cancer using 1H NMR-based metabolomics publication-title: Neoplasia doi: 10.1593/neo.81396 – volume: 66 start-page: 3 year: 2015 end-page: 9 ident: CR37 article-title: Saliva and oxidative stress in oral cavity and in some systemic disorders publication-title: J Physiol Pharmacol – volume: 452 start-page: 18 year: 2016 end-page: 26 ident: CR43 article-title: Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry publication-title: Clin Chim Acta doi: 10.1016/j.cca.2015.10.032 – volume: 15 start-page: 5473 year: 2009 end-page: 5477 ident: CR22 article-title: Salivary microRNA: discovery, characterization and clinical utility for oral cancer detection publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-09-0736 – volume: 44 start-page: 477 year: 2008 end-page: 483 ident: CR29 article-title: A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2007.06.007 – volume: 121 start-page: 971 year: 2011 end-page: 977 ident: CR44 article-title: Clinical significance of preoperative squamous cell carcinoma antigen in oral-cavity squamous cell carcinoma publication-title: Laryngoscope doi: 10.1002/lary.21721 – volume: 99 start-page: 117 year: 1989 end-page: 124 ident: CR45 article-title: SCC-RIA in the diagnosis of squamous cell carcinoma of the head and neck publication-title: Laryngoscope doi: 10.1288/00005537-198902000-00001 – volume: 128 start-page: 313 year: 2002 end-page: 318 ident: CR5 article-title: Predictive factors for diagnosis of advanced-stage squamous cell carcinoma of the head and neck publication-title: Arch Otolaryngol Head Neck Surg doi: 10.1001/archotol.128.3.313 – volume: 583 start-page: 1215 year: 2009 end-page: 1225 ident: CR39 article-title: Homocysteine and lipids: S-adenosyl methionine as a key intermediate publication-title: FEBS Lett doi: 10.1016/j.febslet.2009.03.038 – volume: 6 start-page: 78 year: 2010 end-page: 95 ident: CR25 article-title: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles publication-title: Metabolomics doi: 10.1007/s11306-009-0178-y – volume: 281 start-page: 16768 year: 2006 end-page: 16776 ident: CR33 article-title: Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption publication-title: J Biol Chem doi: 10.1074/jbc.M601876200 – volume: 85 start-page: 11835 year: 2013 end-page: 11842 ident: CR52 article-title: High-throughput LC-MS/MS based simultaneous determination of polyamines including N-acetylated forms in human saliva and the diagnostic approach to breast cancer patients publication-title: Anal Chem doi: 10.1021/ac402526c – volume: 69 start-page: 4918 year: 2009 end-page: 4925 ident: CR51 article-title: Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-4806 – volume: 59 start-page: 225 year: 2009 end-page: 249 ident: CR1 article-title: Cancer statistics publication-title: CA Cancer J Clin doi: 10.3322/caac.20006 – volume: 10 start-page: 471 year: 1996 end-page: 480 ident: CR38 article-title: S-Adenosylmethionine and methylation publication-title: FASEB J doi: 10.1096/fasebj.10.4.8647346 – volume: 129 start-page: 2207 year: 2011 end-page: 2217 ident: CR24 article-title: Salivary metabolite signatures of oral cancer and leukoplakia publication-title: Int J Cancer doi: 10.1002/ijc.25881 – volume: 427 start-page: 79 year: 2014 end-page: 85 ident: CR28 article-title: Investigation and identification of potential biomarkers in human saliva for the early diagnosis of oral squamous cell carcinoma publication-title: Clin Chim Acta doi: 10.1016/j.cca.2013.10.004 – ident: CR42 – volume: 7 start-page: 229 year: 1995 end-page: 233 ident: CR3 article-title: Molecular genetics of head and neck cancer publication-title: Curr Opin Oncol doi: 10.1097/00001622-199505000-00007 – volume: 68 start-page: 617 year: 2002 end-page: 621 ident: CR9 article-title: Advances in the diagnosis of oral premalignant and malignant lesions publication-title: J Can Dent Assoc – ident: CR21 – volume: 9 start-page: 34 year: 2013 ident: CR7 article-title: Significant improvement in temporary dental rehabilitation by notable miniplate application in the hard palate for a patient with a large anterior maxillary defect: a case report/technique article publication-title: Head Face Med doi: 10.1186/1746-160X-9-34 – volume: 21 start-page: 664 year: 2012 end-page: 672 ident: CR23 article-title: Prevalidation of salivary biomarkers for oral cancer detection publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-11-1093 – volume: 23 start-page: 5173 year: 2003 end-page: 5179 ident: CR53 article-title: S-adenosylmethionine (AdoMet) supplementation for treatment of chemotherapy-induced liver injury publication-title: Anticancer Res – volume: 19 start-page: 3856 year: 2012 end-page: 3864 ident: CR19 article-title: Risk stratification in oral cavity squamous cell carcinoma by preoperative CRP and SCC antigen levels publication-title: Ann Surg Oncol doi: 10.1245/s10434-012-2392-5 – volume: 26 start-page: 488 year: 2014 end-page: 491 ident: CR6 article-title: Acantholytic squamous cell carcinoma of the maxillary gingiva: A case report ~ The third case of ASCC to affect the maxillirary gingiva ~ publication-title: Journal of Oral and Maxillofacial Surgery, Medicine and Pathology doi: 10.1016/j.ajoms.2013.04.008 – volume: 138 start-page: 949 year: 2010 end-page: 957 ident: CR49 article-title: Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.11.010 – volume: 328 start-page: 184 year: 1993 end-page: 194 ident: CR2 article-title: Head and neck cancer publication-title: N Engl J Med doi: 10.1056/NEJM199301213280306 – volume: 14 start-page: 6246 year: 2008 end-page: 6252 ident: CR47 article-title: Salivary proteomics for oral cancer biomarker discovery publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-07-5037 – volume: 411 start-page: 134 year: 2006 end-page: 193 ident: CR36 article-title: [9] TM4 microarray software suite publication-title: Methods in enzymology doi: 10.1016/S0076-6879(06)11009-5 – volume: 8 start-page: 2173 year: 2009 end-page: 2185 ident: CR15 article-title: Serum proteomic approach for the identification of serum biomarkers contributed by oral squamous cell carcinoma and host tissue microenvironment publication-title: J Proteome Res doi: 10.1021/pr800979e – ident: CR26 – volume: 37 start-page: 125 year: 2009 end-page: 129 ident: CR14 article-title: Proteomic diagnosis models from serum for early detection of oral squamous cell carcinoma publication-title: Artif Cells Blood Substit Immobil Biotechnol doi: 10.1080/10731190902913759 – volume: 9 start-page: e103265 year: 2014 ident: CR46 article-title: Using SCC antigen and CRP levels as prognostic biomarkers in recurrent oral cavity squamous cell carcinoma publication-title: Plos One doi: 10.1371/journal.pone.0103265 – volume: 10 start-page: 8442 year: 2004 end-page: 8450 ident: CR20 article-title: Salivary transcriptome diagnostics for oral cancer detection publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-04-1167 – volume: 5 start-page: 299 year: 1996 end-page: 314 ident: CR35 article-title: R: a language for data analysis and graphics publication-title: Journal of computational and graphical statistics – volume: 19 start-page: 3032 year: 2013 end-page: 3038 ident: CR30 article-title: Discovery and prevalidation of salivary extracellular microRNA biomarkers panel for the noninvasive detection of benign and malignant parotid gland tumors publication-title: Clin Cancer Res – volume: 791 start-page: 36 year: 2013 end-page: 45 ident: CR41 article-title: Determination of polyamine metabolome in plasma and urine by ultrahigh performance liquid chromatography-tandem mass spectrometry method: Application to identify potential markers for human hepatic cancer publication-title: Analytica Chimica Acta doi: 10.1016/j.aca.2013.06.044 – volume: 19 start-page: 517 year: 1998 end-page: 526 ident: CR17 article-title: SCC antigen in malignant and nonmalignant squamous lesions publication-title: Tumour Biol doi: 10.1159/000030045 – volume: 81 start-page: 9188 year: 2009 end-page: 9193 ident: CR27 article-title: Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification publication-title: Anal Chem doi: 10.1021/ac9020598 – volume: 9 start-page: 454 year: 2013 end-page: 463 ident: CR34 article-title: Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles publication-title: Metabolomics doi: 10.1007/s11306-012-0464-y – volume: 27 start-page: 233 year: 2013 end-page: 243 ident: CR32 article-title: Changes of metabolic profiles in an oral squamous cell carcinoma cell line induced by eugenol publication-title: In Vivo – volume: 6 start-page: 3878 year: 2000 end-page: 3884 ident: CR40 article-title: Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N’-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme publication-title: Clin Cancer Res – volume: 25 start-page: 93 year: 2010 end-page: 98 ident: CR18 article-title: Serum SCCA, Cyfra 21-1, EGFR and Cyclin D1 levels in patients with oral squamous cell carcinoma publication-title: Int J Biol Markers doi: 10.1177/172460081002500206 – volume: 16 start-page: 48 year: 2015 ident: CR11 article-title: Little evidence for the effectiveness of chemiluminescence and autofluorescent imaging devices as oral cancer screening adjuncts publication-title: Evid Based Dent doi: 10.1038/sj.ebd.6401094 – volume: 66 start-page: 7 year: 2016 end-page: 30 ident: CR8 article-title: Cancer statistics publication-title: CA Cancer J Clin doi: 10.3322/caac.21332 – volume: 141 start-page: 509 year: 2010 end-page: 520 ident: CR10 article-title: Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas publication-title: J Am Dent Assoc doi: 10.14219/jada.archive.2010.0223 – volume: 3 start-page: 1056 year: 2010 end-page: 1059 ident: CR4 article-title: Screening for oral premalignancy and cancer: what platform and which biomarkers? publication-title: Cancer Prev Res (Phila) doi: 10.1158/1940-6207.CAPR-10-0173 – volume: 694 start-page: 72 year: 1993 end-page: 77 ident: CR48 article-title: Methods for collecting saliva publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.1993.tb18343.x – volume: 39 start-page: 171 year: 2011 end-page: 176 ident: CR12 article-title: Assessing the usefulness of three adjunctive diagnostic devices for oral cancer screening: a probabilistic approach publication-title: Community Dent Oral Epidemiol doi: 10.1111/j.1600-0528.2010.00579.x – volume: 43 start-page: 38 year: 1972 ident: CR50 article-title: The plaque control record publication-title: J Periodontol doi: 10.1902/jop.1972.43.1.38 – volume: 118 start-page: 218 year: 2014 end-page: 225 ident: CR31 article-title: Glucose and glutamine metabolism in oral squamous cell carcinoma: insight from a quantitative metabolomic approach publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol doi: 10.1016/j.oooo.2014.04.003 – volume: 11 start-page: 3106 year: 2010 end-page: 3121 ident: CR13 article-title: Identification of tetranectin as a potential biomarker for metastatic oral cancer publication-title: Int J Mol Sci doi: 10.3390/ijms11093106 – volume: 9 start-page: 34 year: 2013 ident: BFsrep31520_CR7 publication-title: Head Face Med doi: 10.1186/1746-160X-9-34 – volume: 66 start-page: 3 year: 2015 ident: BFsrep31520_CR37 publication-title: J Physiol Pharmacol – volume: 8 start-page: 2173 year: 2009 ident: BFsrep31520_CR15 publication-title: J Proteome Res doi: 10.1021/pr800979e – volume: 39 start-page: 171 year: 2011 ident: BFsrep31520_CR12 publication-title: Community Dent Oral Epidemiol doi: 10.1111/j.1600-0528.2010.00579.x – volume: 19 start-page: 3856 year: 2012 ident: BFsrep31520_CR19 publication-title: Ann Surg Oncol doi: 10.1245/s10434-012-2392-5 – volume: 129 start-page: 2207 year: 2011 ident: BFsrep31520_CR24 publication-title: Int J Cancer doi: 10.1002/ijc.25881 – volume: 23 start-page: 5173 year: 2003 ident: BFsrep31520_CR53 publication-title: Anticancer Res – volume: 59 start-page: 225 year: 2009 ident: BFsrep31520_CR1 publication-title: CA Cancer J Clin doi: 10.3322/caac.20006 – volume: 141 start-page: 509 year: 2010 ident: BFsrep31520_CR10 publication-title: J Am Dent Assoc doi: 10.14219/jada.archive.2010.0223 – volume: 128 start-page: 313 year: 2002 ident: BFsrep31520_CR5 publication-title: Arch Otolaryngol Head Neck Surg doi: 10.1001/archotol.128.3.313 – volume: 15 start-page: 5473 year: 2009 ident: BFsrep31520_CR22 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-09-0736 – volume: 791 start-page: 36 year: 2013 ident: BFsrep31520_CR41 publication-title: Analytica Chimica Acta doi: 10.1016/j.aca.2013.06.044 – volume: 411 start-page: 134 year: 2006 ident: BFsrep31520_CR36 publication-title: Methods in enzymology doi: 10.1016/S0076-6879(06)11009-5 – volume: 66 start-page: 7 year: 2016 ident: BFsrep31520_CR8 publication-title: CA Cancer J Clin doi: 10.3322/caac.21332 – volume: 10 start-page: 8442 year: 2004 ident: BFsrep31520_CR20 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-04-1167 – volume: 9 start-page: 454 year: 2013 ident: BFsrep31520_CR34 publication-title: Metabolomics doi: 10.1007/s11306-012-0464-y – volume: 25 start-page: 93 year: 2010 ident: BFsrep31520_CR18 publication-title: Int J Biol Markers doi: 10.1177/172460081002500206 – volume: 694 start-page: 72 year: 1993 ident: BFsrep31520_CR48 publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.1993.tb18343.x – volume: 281 start-page: 16768 year: 2006 ident: BFsrep31520_CR33 publication-title: J Biol Chem doi: 10.1074/jbc.M601876200 – volume: 5 start-page: 299 year: 1996 ident: BFsrep31520_CR35 publication-title: Journal of computational and graphical statistics doi: 10.1080/10618600.1996.10474713 – volume: 118 start-page: 218 year: 2014 ident: BFsrep31520_CR31 publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol doi: 10.1016/j.oooo.2014.04.003 – volume: 69 start-page: 4918 year: 2009 ident: BFsrep31520_CR51 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-4806 – volume: 11 start-page: 269 year: 2009 ident: BFsrep31520_CR16 publication-title: Neoplasia doi: 10.1593/neo.81396 – volume: 68 start-page: 617 year: 2002 ident: BFsrep31520_CR9 publication-title: J Can Dent Assoc – volume: 19 start-page: 3032 year: 2013 ident: BFsrep31520_CR30 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-12-3505 – volume: 121 start-page: 971 year: 2011 ident: BFsrep31520_CR44 publication-title: Laryngoscope doi: 10.1002/lary.21721 – volume: 37 start-page: 125 year: 2009 ident: BFsrep31520_CR14 publication-title: Artif Cells Blood Substit Immobil Biotechnol doi: 10.1080/10731190902913759 – volume: 10 start-page: 471 year: 1996 ident: BFsrep31520_CR38 publication-title: FASEB J doi: 10.1096/fasebj.10.4.8647346 – volume: 44 start-page: 477 year: 2008 ident: BFsrep31520_CR29 publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2007.06.007 – volume: 6 start-page: 78 year: 2010 ident: BFsrep31520_CR25 publication-title: Metabolomics doi: 10.1007/s11306-009-0178-y – volume: 43 start-page: 38 year: 1972 ident: BFsrep31520_CR50 publication-title: J Periodontol doi: 10.1902/jop.1972.43.1.38 – volume: 328 start-page: 184 year: 1993 ident: BFsrep31520_CR2 publication-title: N Engl J Med doi: 10.1056/NEJM199301213280306 – volume: 26 start-page: 488 year: 2014 ident: BFsrep31520_CR6 publication-title: Journal of Oral and Maxillofacial Surgery, Medicine and Pathology doi: 10.1016/j.ajoms.2013.04.008 – volume: 9 start-page: e103265 year: 2014 ident: BFsrep31520_CR46 publication-title: Plos One doi: 10.1371/journal.pone.0103265 – volume: 452 start-page: 18 year: 2016 ident: BFsrep31520_CR43 publication-title: Clin Chim Acta doi: 10.1016/j.cca.2015.10.032 – volume: 81 start-page: 9188 year: 2009 ident: BFsrep31520_CR27 publication-title: Anal Chem doi: 10.1021/ac9020598 – volume: 11 start-page: 3106 year: 2010 ident: BFsrep31520_CR13 publication-title: Int J Mol Sci doi: 10.3390/ijms11093106 – volume: 99 start-page: 117 year: 1989 ident: BFsrep31520_CR45 publication-title: Laryngoscope doi: 10.1288/00005537-198902000-00001 – volume: 27 start-page: 233 year: 2013 ident: BFsrep31520_CR32 publication-title: In Vivo – ident: BFsrep31520_CR21 doi: 10.1158/1078-0432.CCR-15-1761 – volume: 16 start-page: 48 year: 2015 ident: BFsrep31520_CR11 publication-title: Evid Based Dent doi: 10.1038/sj.ebd.6401094 – volume: 6 start-page: 3878 year: 2000 ident: BFsrep31520_CR40 publication-title: Clin Cancer Res – ident: BFsrep31520_CR26 doi: 10.4172/2153-0769.1000128 – ident: BFsrep31520_CR42 doi: 10.1371/journal.pone.0062375 – volume: 7 start-page: 229 year: 1995 ident: BFsrep31520_CR3 publication-title: Curr Opin Oncol doi: 10.1097/00001622-199505000-00007 – volume: 21 start-page: 664 year: 2012 ident: BFsrep31520_CR23 publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-11-1093 – volume: 427 start-page: 79 year: 2014 ident: BFsrep31520_CR28 publication-title: Clin Chim Acta doi: 10.1016/j.cca.2013.10.004 – volume: 19 start-page: 517 year: 1998 ident: BFsrep31520_CR17 publication-title: Tumour Biol doi: 10.1159/000030045 – volume: 583 start-page: 1215 year: 2009 ident: BFsrep31520_CR39 publication-title: FEBS Lett doi: 10.1016/j.febslet.2009.03.038 – volume: 3 start-page: 1056 year: 2010 ident: BFsrep31520_CR4 publication-title: Cancer Prev Res (Phila) doi: 10.1158/1940-6207.CAPR-10-0173 – volume: 14 start-page: 6246 year: 2008 ident: BFsrep31520_CR47 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-07-5037 – volume: 138 start-page: 949 year: 2010 ident: BFsrep31520_CR49 publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.11.010 – volume: 85 start-page: 11835 year: 2013 ident: BFsrep31520_CR52 publication-title: Anal Chem doi: 10.1021/ac402526c |
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| Title | Identification of salivary metabolomic biomarkers for oral cancer screening |
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