The Cost-Effectiveness of Mandatory Folic Acid Fortification in Australia

The Australian government recently introduced mandatory folic acid fortification of bread to reduce the incidence of neural tube defects (NTDs). The economic evaluation of this policy contained a number of limitations. This study aimed to address the limitations and to reconsider the findings. Cost-...

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Published inThe Journal of nutrition Vol. 143; no. 1; pp. 59 - 66
Main Authors Rabovskaja, Viktoria, Parkinson, Bonny, Goodall, Stephen
Format Journal Article
LanguageEnglish
Published Bethesda, MD Elsevier Inc 01.01.2013
American Society for Nutrition
Subjects
HUI
LYG
NTD
PSA
WTP
WTP
LYG
HUI
NTD
PSA
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Abstract The Australian government recently introduced mandatory folic acid fortification of bread to reduce the incidence of neural tube defects (NTDs). The economic evaluation of this policy contained a number of limitations. This study aimed to address the limitations and to reconsider the findings. Cost-effectiveness analysis was used to assess the cost and benefits of mandatory versus voluntary folic acid fortification. Outcomes measures were quality-adjusted life-years (QALYs), life-years gained (LYG), avoided NTD cases, and additional severe neuropathy cases. Costs considered included industry costs and regulatory costs to the government. It was estimated that mandatory fortification would prevent 31 NTDs, whereas an additional 14 cases of severe neuropathy would be incurred. Overall, 539 LYG and 503 QALYs would be gained per year of mandatory compared with voluntary fortification. Mandatory fortification was cost-effective at A$10,723 per LYG and at A$11,485 per QALY. Probabilistic sensitivity analysis showed that at A$60,000 and A$151,000 per QALY, the probability that mandatory fortification was the most cost-effective strategy was 79% and 85%, respectively. Threshold analysis of loss of consumer choice indicated that with a compensation value above A$1.21 [assuming a willingness to pay (WTP) threshold of A$60,000 per QALY] or A$3.19 (assuming a WTP threshold of A$151,000 per statistical life-year) per capita per year mandatory fortification would not be cost-effective. Mandatory fortification was found to be cost-effective; however, inclusion of the loss of consumer choice can change this result. Even with mandatory fortification, mean folate intake will remain below the recommended NTD preventive level.
AbstractList The Australian government recently introduced mandatory folic acid fortification of bread to reduce the incidence of neural tube defects (NTDs). The economic evaluation of this policy contained a number of limitations. This study aimed to address the limitations and to reconsider the findings. Cost-effectiveness analysis was used to assess the cost and benefits of mandatory versus voluntary folic acid fortification. Outcomes measures were quality-adjusted life-years (QALYs), life-years gained (LYG), avoided NTD cases, and additional severe neuropathy cases. Costs considered included industry costs and regulatory costs to the government. It was estimated that mandatory fortification would prevent 31 NTDs, whereas an additional 14 cases of severe neuropathy would be incurred. Overall, 539 LYG and 503 QALYs would be gained per year of mandatory compared with voluntary fortification. Mandatory fortification was cost-effective at A$10,723 per LYG and at A$11,485 per QALY. Probabilistic sensitivity analysis showed that at A$60,000 and A$151,000 per QALY, the probability that mandatory fortification was the most cost-effective strategy was 79% and 85%, respectively. Threshold analysis of loss of consumer choice indicated that with a compensation value above A$1.21 [assuming a willingness to pay (WTP) threshold of A$60,000 per QALY] or A$3.19 (assuming a WTP threshold of A$151,000 per statistical life-year) per capita per year mandatory fortification would not be cost-effective. Mandatory fortification was found to be cost-effective; however, inclusion of the loss of consumer choice can change this result. Even with mandatory fortification, mean folate intake will remain below the recommended NTD preventive level.
Author Parkinson, Bonny
Goodall, Stephen
Rabovskaja, Viktoria
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Issue 1
Keywords FSANZ
PBAC
WTP
DALY
ICER
QALY
LYG
HUI
NTD
PSA
Micronutrient
Nutrition
Folic acid
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Snippet The Australian government recently introduced mandatory folic acid fortification of bread to reduce the incidence of neural tube defects (NTDs). The economic...
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pubmed
pascalfrancis
elsevier
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Index Database
Publisher
StartPage 59
SubjectTerms Australia - epidemiology
Biological and medical sciences
Bread - adverse effects
Bread - analysis
Bread - economics
Cost-Benefit Analysis
DALY
Decision Trees
disability-adjusted life-year
Feeding. Feeding behavior
Folic Acid - administration & dosage
Folic Acid - adverse effects
Folic Acid - economics
Food Standards Australia New Zealand
Food, Fortified - adverse effects
Food, Fortified - economics
FSANZ
Fundamental and applied biological sciences. Psychology
Government Programs - economics
Health Promotion - economics
Health Utility Index
HUI
Humans
ICER
Incidence
incremental cost-effectiveness ratio
life-year gained
LYG
Mandatory Programs - economics
neural tube defect
Neural Tube Defects - economics
Neural Tube Defects - epidemiology
Neural Tube Defects - prevention & control
NTD
PBAC
Peripheral Nervous System Diseases - economics
Peripheral Nervous System Diseases - epidemiology
Peripheral Nervous System Diseases - etiology
Peripheral Nervous System Diseases - physiopathology
Pharmaceutical Benefits Advisory Committee
Prevalence
probabilistic sensitivity analysis
PSA
QALY
Quality-Adjusted Life Years
quality-adjusted life-year
Severity of Illness Index
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin B 12 Deficiency - economics
Vitamin B 12 Deficiency - epidemiology
Vitamin B 12 Deficiency - physiopathology
Voluntary Programs - economics
willingness to pay
WTP
Title The Cost-Effectiveness of Mandatory Folic Acid Fortification in Australia
URI https://dx.doi.org/10.3945/jn.112.166694
https://www.ncbi.nlm.nih.gov/pubmed/23223683
Volume 143
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