Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer’s Disease

• Published in: Biomedicines Vol. 9; no. 11; p. 1587
• Main Authors: Yao, Pamela J., Eren, Erden, Goetzl, Edward J., Kapogiannis, Dimitrios
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 31.10.2021; MDPI
• Subjects: Alzheimer's disease; ATP synthase; Autopsy; Biomarkers; Brain research; Cloning; Cytochrome; Electroconvulsive therapy; Electron transport chain; Enzymes; Extracellular vesicles; Mitochondria; NADH; Nanoparticles; Neurodegeneration; Neurodegenerative diseases; Oxidative phosphorylation; Phosphorylation; Plasma; Protein transport; Proteins; Reactive oxygen species; Reagents; Superoxide dismutase; Superoxide Dismutase 1; United States > US; San Francisco California

Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1). Dysfunctional mitochondria, manifesting decreased activity of electron transport chain (ETC) complexes and high ROS levels, are involved in Alzh...