Tebuconazole induced oxidative stress related hepatotoxicity in adult and larval zebrafish (Danio rerio)

• Published in: Chemosphere (Oxford) Vol. 241; p. 125129
• Main Authors: Li, Shuying, Jiang, Yao, Sun, Qianqian, Coffin, Scott, Chen, Lili, Qiao, Kun, Gui, Wenjun, Zhu, Guonian
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2020
• Subjects: acridine orange; adults; alanine transaminase; animal models; Animals; Apoptosis; Apoptosis - drug effects; aspartate transaminase; catalase; Catalase - metabolism; Chemical and Drug Induced Liver Injury; Danio rerio; depuration; enzyme activity; Female; females; fish larvae; fluorescence; Fungicides, Industrial - toxicity; glutathione transferase; Hepatotoxicity; histopathology; humans; juveniles; Larva - drug effects; liver; Male; males; oxidative stress; Oxidative Stress - drug effects; peroxidase; Reactive oxygen species; Reactive Oxygen Species - metabolism; staining; superoxide dismutase; Superoxide Dismutase - metabolism; Tebuconazole; Triazoles - pharmacology; Triazoles - toxicity; Zebrafish; Zebrafish - metabolism; Zebrafish; Reactive oxygen species; Tebuconazole; Hepatotoxicity; Apoptosis

Tebuconazole is widely used as fungicide and has frequently been detected at elevated concentrations in environmental media. To characterize the potential toxicity of tebuconazole on vertebrate and humans. Using zebrafish as a vertebrate model, the toxic effects in liver that produced by low-toxic c...