Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

• Published in: American journal of physiology: endocrinology and metabolism Vol. 298; no. 6; pp. E1161 - E1169
• Main Authors: Dray, Cédric, Debard, Cyrille, Jager, Jennifer, Disse, Emmanuel, Daviaud, Danièle, Martin, Pascal, Attané, Camille, Wanecq, Estelle, Guigné, Charlotte, Bost, Frédéric, Tanti, Jean-François, Laville, Martine, Vidal, Hubert, Valet, Philippe, Castan-Laurell, Isabelle
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2010
• Subjects: Adipokines; Adipose tissue; Adipose Tissue - metabolism; Adipose Tissue - physiology; Adult; Animals; Apelin; Apelin Receptors; Biochemistry, Molecular Biology; Carrier Proteins - biosynthesis; Carrier Proteins - genetics; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Endocrinology; Female; Gene Expression Regulation; Glucose Clamp Technique; Humans; Insulin - blood; Insulin Resistance - physiology; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - genetics; Leptin - blood; Life Sciences; Male; Metabolism; Mice; Mice, Inbred C57BL; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Musculoskeletal system; Obesity; Plasma; Receptors, G-Protein-Coupled - biosynthesis; Receptors, G-Protein-Coupled - genetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Tissues; RNA; Humans; Middle Aged; Male; Skeletal; Receptors; Type 2; Adult; Female; Muscle; Adipose Tissue; Carrier Proteins; G-Protein-Coupled; Intercellular Signaling Peptides and Proteins; Gene Expression Regulation; Insulin Resistance; Messenger; Diabetes Mellitus; Reverse Transcriptase Polymerase Chain Reaction; Insulin; Inbred C57BL; Animals; Leptin; Mice; Glucose Clamp Technique

Apelin, an adipocyte-secreted factor upregulated by insulin, is increased in adipose tissue (AT) and plasma with obesity. Apelin was recently identified as a new player in the control of glucose homeostasis. However, the regulation of apelin and APJ (apelin receptor) expression in skeletal muscle in...