Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy

Saved in:
Bibliographic Details
Published inBrain (London, England : 1878) Vol. 136; no. Pt 2; p. e230
Main Authors Klopstock, T, Metz, G, Yu-Wai-Man, P, Büchner, B, Gallenmüller, C, Bailie, M, Nwali, N, Griffiths, P G, von Livonius, B, Reznicek, L, Rouleau, J, Coppard, N, Meier, T, Chinnery, P F
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.02.2013
Subjects
Adolescent
Adult
Aged
Cohort Studies
Double-Blind Method
Female
Follow-Up Studies
Humans
Letters to the Editor
Male
Middle Aged
Optic Atrophy, Hereditary, Leber - drug therapy
Optic Atrophy, Hereditary, Leber - epidemiology
Optic Atrophy, Hereditary, Leber - physiopathology
Time Factors
Treatment Outcome
Ubiquinone - analogs & derivatives
Ubiquinone - pharmacology
Ubiquinone - therapeutic use
Visual Acuity - drug effects
Visual Acuity - physiology
Young Adult
Online AccessGet full text

Cover

Author Metz, G
Meier, T
Reznicek, L
Nwali, N
Coppard, N
Gallenmüller, C
Rouleau, J
Büchner, B
von Livonius, B
Yu-Wai-Man, P
Chinnery, P F
Griffiths, P G
Klopstock, T
Bailie, M
AuthorAffiliation 2 Santhera Pharmaceuticals, 4410 Liestal, Switzerland
6 Department of Ophthalmology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec H2L 4M1, Canada
1 Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University, 80336 Munich, Germany
5 Department of Ophthalmology, Ludwig-Maximilians-University, Munich 80336, Germany
3 Departments of Neurology and Ophthalmology, Newcastle upon Tyne Foundation Hospital NHS Foundation Trust, NE1 4LP UK
4 Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK
AuthorAffiliation_xml – name: 3 Departments of Neurology and Ophthalmology, Newcastle upon Tyne Foundation Hospital NHS Foundation Trust, NE1 4LP UK
– name: 5 Department of Ophthalmology, Ludwig-Maximilians-University, Munich 80336, Germany
– name: 2 Santhera Pharmaceuticals, 4410 Liestal, Switzerland
– name: 4 Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK
– name: 1 Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University, 80336 Munich, Germany
– name: 6 Department of Ophthalmology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec H2L 4M1, Canada
Author_xml – sequence: 1
  givenname: T
  surname: Klopstock
  fullname: Klopstock, T
– sequence: 2
  givenname: G
  surname: Metz
  fullname: Metz, G
– sequence: 3
  givenname: P
  surname: Yu-Wai-Man
  fullname: Yu-Wai-Man, P
– sequence: 4
  givenname: B
  surname: Büchner
  fullname: Büchner, B
– sequence: 5
  givenname: C
  surname: Gallenmüller
  fullname: Gallenmüller, C
– sequence: 6
  givenname: M
  surname: Bailie
  fullname: Bailie, M
– sequence: 7
  givenname: N
  surname: Nwali
  fullname: Nwali, N
– sequence: 8
  givenname: P G
  surname: Griffiths
  fullname: Griffiths, P G
– sequence: 9
  givenname: B
  surname: von Livonius
  fullname: von Livonius, B
– sequence: 10
  givenname: L
  surname: Reznicek
  fullname: Reznicek, L
– sequence: 11
  givenname: J
  surname: Rouleau
  fullname: Rouleau, J
– sequence: 12
  givenname: N
  surname: Coppard
  fullname: Coppard, N
– sequence: 13
  givenname: T
  surname: Meier
  fullname: Meier, T
– sequence: 14
  givenname: P F
  surname: Chinnery
  fullname: Chinnery, P F
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23388409$$D View this record in MEDLINE/PubMed
BookMark eNpVkMtLAzEQxoNU7ENvniU3L67Nax-5CFJ8QUEPBY8hm524kTZbklTpf-_WatHTDDPffPPxG6OB7zwgdE7JNSWST-ugnZ_qz8hKeYRGVBQkYzQvBmhECCmySuZkiMYxvhNCBWfFCRoyzqtKEDlCry8QoosJvAHcWZxawCmATivwCYO1YNJu7hqoYfcZO4_nfR8uI24hQOOSDlvcrZMz2MMmdGud2u0pOrZ6GeHsp07Q4v5uMXvM5s8PT7PbeWZEWaTM1ASEyKsi50LUjdFWWqYrA0A1q8CWIGhdNUwY4CSXVuaNpJTownBNbMMn6GZvu97UK2hMHzropVoHt-pTqU479X_jXaveug_F85JJTnuDq72BCV2MAezhlhK146u--ao9315-8fffQfwLlH8B0oF9hg
CitedBy_id crossref_primary_10_1016_j_ebiom_2021_103244
crossref_primary_10_29014_ns_2018_31
crossref_primary_10_1016_j_neurol_2014_03_009
crossref_primary_10_1016_j_ymgme_2020_06_011
crossref_primary_10_1111_jfbc_13230
crossref_primary_10_1038_nrneurol_2014_228
crossref_primary_10_1080_02713683_2020_1736307
crossref_primary_10_3390_ijms241612580
crossref_primary_10_1007_s10384_020_00789_2
crossref_primary_10_3390_life13102000
crossref_primary_10_1177_2326409817752960
crossref_primary_10_1159_000381726
crossref_primary_10_1038_eye_2014_37
crossref_primary_10_1016_j_ajo_2022_11_004
crossref_primary_10_1146_annurev_vision_102016_061422
crossref_primary_10_1016_j_omtn_2022_10_012
crossref_primary_10_1016_j_spen_2017_06_001
crossref_primary_10_1016_j_pharmthera_2016_06_004
crossref_primary_10_1177_2326409817731112
crossref_primary_10_1212_WNL_0000000000013084
crossref_primary_10_3390_jcm9041112
crossref_primary_10_1016_j_neurot_2023_e00311
crossref_primary_10_1080_01658107_2022_2032761
crossref_primary_10_1016_j_freeradbiomed_2015_05_041
crossref_primary_10_1097_APO_0000000000000220
crossref_primary_10_1007_s40265_020_01428_3
crossref_primary_10_1016_j_crvi_2013_11_011
crossref_primary_10_1021_acs_bioconjchem_0c00470
crossref_primary_10_3390_antiox12071464
crossref_primary_10_3390_medicina57030202
crossref_primary_10_1517_21678707_2015_1098531
crossref_primary_10_4103_tjo_tjo_68_20
crossref_primary_10_3390_cells12152013
crossref_primary_10_3390_pharmaceutics12111083
crossref_primary_10_1016_S1474_4422_13_70158_3
crossref_primary_10_1093_hmg_ddv396
crossref_primary_10_1097_ICU_0000000000000891
crossref_primary_10_1007_s12325_018_0776_z
crossref_primary_10_1155_2015_835986
crossref_primary_10_1016_j_oftal_2016_06_005
crossref_primary_10_1016_j_preteyeres_2024_101264
crossref_primary_10_3390_ph13080184
crossref_primary_10_1097_WNO_0000000000000570
crossref_primary_10_1016_j_ijpharm_2014_12_044
crossref_primary_10_1097_ICU_0000000000000410
crossref_primary_10_1097_OPX_0000000000000991
crossref_primary_10_1016_j_oftale_2016_09_008
crossref_primary_10_1038_nrdp_2016_80
crossref_primary_10_1007_s11910_022_01246_y
crossref_primary_10_1111_ene_15847
crossref_primary_10_5692_clinicalneurol_cn_001924
crossref_primary_10_1080_10837450_2016_1231811
crossref_primary_10_1016_j_ymgme_2020_10_002
crossref_primary_10_1080_01658107_2016_1213860
crossref_primary_10_1097_IIO_0000000000000364
crossref_primary_10_1002_glia_22670
crossref_primary_10_1016_j_mito_2017_01_004
crossref_primary_10_1016_j_omtn_2021_08_015
crossref_primary_10_1016_j_addr_2020_09_010
crossref_primary_10_1016_j_ebiom_2017_02_013
crossref_primary_10_1177_0883073814538509
crossref_primary_10_1007_s00401_016_1625_2
crossref_primary_10_3390_genes12010112
crossref_primary_10_1038_s41434_022_00333_6
crossref_primary_10_1080_13816810_2020_1755988
crossref_primary_10_3390_ph13020029
crossref_primary_10_1007_s00417_020_04993_1
crossref_primary_10_1080_13102818_2023_2255073
crossref_primary_10_1126_science_1250256
crossref_primary_10_1016_j_mito_2016_11_006
crossref_primary_10_1177_0883073813492895
crossref_primary_10_4103_ijo_IJO_358_17
crossref_primary_10_1056_NEJMcpc1900597
crossref_primary_10_1016_S1474_4422_22_00174_0
crossref_primary_10_33549_physiolres_934529
crossref_primary_10_1016_j_jfo_2013_05_007
crossref_primary_10_1016_j_praneu_2016_01_010
crossref_primary_10_1097_WNO_0000000000000830
crossref_primary_10_3390_cells12010020
crossref_primary_10_1002_adma_202103307
crossref_primary_10_1517_21678707_2016_1117972
crossref_primary_10_1167_tvst_10_8_4
crossref_primary_10_3390_pharmaceutics15020322
crossref_primary_10_1016_j_ymgme_2017_09_009
crossref_primary_10_1212_01_wnl_0000437308_22603_43
crossref_primary_10_1016_j_phrs_2018_09_024
crossref_primary_10_1007_s40265_016_0574_3
crossref_primary_10_1016_j_mito_2023_01_006
crossref_primary_10_3390_antiox11112293
crossref_primary_10_3389_fneur_2021_651639
crossref_primary_10_1093_brain_aww058
crossref_primary_10_1007_s00347_019_0864_8
crossref_primary_10_1136_bjophthalmol_2021_320580
crossref_primary_10_1146_annurev_vision_082114_035651
crossref_primary_10_1111_exd_12484
crossref_primary_10_1016_S0181_5512_22_00447_8
crossref_primary_10_1016_j_clnesp_2022_06_016
crossref_primary_10_3390_antiox10121948
crossref_primary_10_1016_j_cell_2020_02_051
crossref_primary_10_1042_EBC20170114
crossref_primary_10_17925_USOR_2023_17_1_21
crossref_primary_10_2174_1570159X15666171109125643
crossref_primary_10_3390_ijms22094793
crossref_primary_10_1186_s12886_017_0583_3
crossref_primary_10_1093_brain_aww085
crossref_primary_10_1097_ICU_0000000000000212
crossref_primary_10_1097_WCO_0000000000000646
crossref_primary_10_1093_bmb_ldv046
crossref_primary_10_3390_jcto2030006
crossref_primary_10_1016_j_ymgme_2014_09_013
crossref_primary_10_3109_08820538_2015_1115251
crossref_primary_10_1016_j_cbpc_2022_109509
crossref_primary_10_1007_s11910_020_01032_8
crossref_primary_10_1002_jmd2_12068
crossref_primary_10_1089_ars_2014_5952
crossref_primary_10_1007_s10384_024_01077_z
crossref_primary_10_1016_j_jfo_2018_06_010
crossref_primary_10_1038_nrneph_2018_9
crossref_primary_10_1080_1028415X_2017_1368170
crossref_primary_10_3390_antiox10020236
crossref_primary_10_3389_fopht_2022_1077395
Cites_doi 10.1016/S0022-510X(96)00311-5
10.4321/S0365-66912007000600012
10.1136/jnnp.71.6.813
10.1093/brain/awr180
10.1016/S0042-6989(97)00444-6
10.1016/S0022-510X(98)00239-1
10.1016/0140-6736(92)91442-B
10.1371/journal.pone.0017963
10.1093/brain/awr170
10.1097/WNO.0b013e318241da45
10.1097/00041327-200020030-00006
ContentType Journal Article
Copyright The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain. 2013
Copyright_xml – notice: The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain. 2013
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
5PM
DOI 10.1093/brain/aws279
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1460-2156
EndPage e230
ExternalDocumentID 10_1093_brain_aws279
23388409
Genre Letter
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
GrantInformation_xml – fundername: Wellcome Trust
  grantid: 101876
– fundername: Medical Research Council
  grantid: G0701386
– fundername: Medical Research Council
  grantid: MR/K000608/1
– fundername: Wellcome Trust
  grantid: 096919
– fundername: Medical Research Council
  grantid: G1002570
GroupedDBID ---
-E4
-~X
.2P
.55
.GJ
.I3
.XZ
.ZR
0R~
1CY
1TH
23N
2WC
354
3O-
4.4
41~
482
48X
53G
5GY
5RE
5VS
5WA
5WD
6.Y
6PF
70D
AABZA
AACZT
AAGKA
AAIMJ
AAJKP
AAJQQ
AAMDB
AAMVS
AAOGV
AAPGJ
AAPNW
AAPQZ
AAPXW
AAQQT
AARHZ
AAUAY
AAUQX
AAVAP
AAVLN
AAWDT
AAWTL
AAYJJ
ABEUO
ABIVO
ABIXL
ABJNI
ABKDP
ABLJU
ABMNT
ABNHQ
ABNKS
ABPTD
ABQLI
ABQNK
ABQTQ
ABSAR
ABSMQ
ABWST
ABXVV
ABZBJ
ACBNA
ACFRR
ACGFS
ACIWK
ACPQN
ACPRK
ACUFI
ACUTJ
ACUTO
ACYHN
ACZBC
ADBBV
ADEYI
ADEZT
ADGKP
ADGZP
ADHKW
ADHZD
ADIPN
ADJQC
ADOCK
ADQBN
ADRIX
ADRTK
ADVEK
ADYVW
ADZXQ
AEGPL
AEHUL
AEJOX
AEKPW
AEKSI
AELWJ
AEMDU
AENEX
AENZO
AEPUE
AETBJ
AEWNT
AFFNX
AFFZL
AFGWE
AFIYH
AFOFC
AFSHK
AFXAL
AFXEN
AFYAG
AGINJ
AGKEF
AGKRT
AGMDO
AGQXC
AGSYK
AGUTN
AHMBA
AHXPO
AI.
AIJHB
AJEEA
AKWXX
ALMA_UNASSIGNED_HOLDINGS
ALUQC
ANFBD
APIBT
APJGH
APWMN
AQDSO
AQKUS
ARIXL
ASAOO
ASPBG
ATDFG
ATGXG
ATTQO
AVNTJ
AVWKF
AXUDD
AYOIW
AZFZN
BAWUL
BAYMD
BCRHZ
BEYMZ
BHONS
BQDIO
BR6
BSWAC
BTRTY
BVRKM
BZKNY
C1A
C45
CAG
CDBKE
CGR
COF
CS3
CUY
CVF
CXTWN
CZ4
DAKXR
DFGAJ
DIK
DILTD
DU5
D~K
E3Z
EBS
ECM
EE~
EIF
EIHJH
EJD
ELUNK
EMOBN
ENERS
F20
F5P
F9B
FECEO
FEDTE
FHSFR
FLUFQ
FOEOM
FOTVD
FQBLK
G8K
GAUVT
GJXCC
GX1
H13
H5~
HAR
HVGLF
HW0
HZ~
IOX
J21
J5H
JXSIZ
KAQDR
KBUDW
KOP
KQ8
KSI
KSN
L7B
M-Z
M49
MBLQV
MBTAY
MHKGH
ML0
MVM
N4W
N9A
NGC
NLBLG
NOMLY
NOYVH
NPM
NTWIH
NU-
NVLIB
O0~
O9-
OAUYM
OAWHX
OBOKY
OCZFY
ODMLO
OHH
OHT
OJQWA
OJZSN
OK1
OPAEJ
OVD
OWPYF
O~Y
P2P
PAFKI
PB-
PEELM
PQQKQ
Q1.
Q5Y
QBD
R44
RD5
RIG
RNI
ROL
ROX
ROZ
RUSNO
RW1
RXO
RZF
RZO
TCN
TCURE
TEORI
TJX
TLC
TMA
TR2
VH1
VVN
W8F
WH7
WOQ
X7H
X7M
XJT
XOL
YAYTL
YKOAZ
YQJ
YSK
YXANX
ZCG
ZGI
ZKB
ZKX
ZXP
~91
AASNB
AAYXX
CITATION
KC5
5PM
ID FETCH-LOGICAL-c476t-cb0e445865344bdcaf9f2a8cee1a28ef7e41b8d24ce3059f95d9110a6c3a0fd3
ISSN 0006-8950
IngestDate Tue Sep 17 20:51:42 EDT 2024
Thu Sep 26 15:45:04 EDT 2024
Wed Oct 16 00:44:10 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue Pt 2
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c476t-cb0e445865344bdcaf9f2a8cee1a28ef7e41b8d24ce3059f95d9110a6c3a0fd3
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC3572931
PMID 23388409
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3572931
crossref_primary_10_1093_brain_aws279
pubmed_primary_23388409
PublicationCentury 2000
PublicationDate 2013-02-01
PublicationDateYYYYMMDD 2013-02-01
PublicationDate_xml – month: 02
  year: 2013
  text: 2013-02-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Brain (London, England : 1878)
PublicationTitleAlternate Brain
PublicationYear 2013
Publisher Oxford University Press
Publisher_xml – name: Oxford University Press
References Klopstock ( key 20170405101931_aws279-B8) 2011; 134
Cortelli ( key 20170405101931_aws279-B5) 1997; 148
Carelli ( key 20170405101931_aws279-B3) 2011; 134
Sabet-Peyman ( key 20170405101931_aws279-B11) 2012; 32
Barnils ( key 20170405101931_aws279-B1) 2007; 82
Mashima ( key 20170405101931_aws279-B9) 1992; 340
Carelli ( key 20170405101931_aws279-B2) 1998; 160
Carelli ( key 20170405101931_aws279-B4) 2001; 71
Mashima ( key 20170405101931_aws279-B10) 2000; 20
Haefeli ( key 20170405101931_aws279-B6) 2011; 6
Howell ( key 20170405101931_aws279-B7) 1998; 38
References_xml – volume: 148
  start-page: 25
  year: 1997
  ident: key 20170405101931_aws279-B5
  article-title: Clinical and brain bioenergetics improvement with idebenone in a patient with Leber's hereditary optic neuropathy: a clinical and 31P-MRS study
  publication-title: J Neurol Sci
  doi: 10.1016/S0022-510X(96)00311-5
  contributor:
    fullname: Cortelli
– volume: 82
  start-page: 377
  year: 2007
  ident: key 20170405101931_aws279-B1
  article-title: Response to idebenone and multivitamin therapy in Leber's hereditary optic neuropathy
  publication-title: Arch Soc Esp Oftalmol
  doi: 10.4321/S0365-66912007000600012
  contributor:
    fullname: Barnils
– volume: 71
  start-page: 813
  year: 2001
  ident: key 20170405101931_aws279-B4
  article-title: Leber's hereditary optic neuropathy (LHON/11778) with myoclonus: report of two cases
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.71.6.813
  contributor:
    fullname: Carelli
– volume: 134
  start-page: e188
  year: 2011
  ident: key 20170405101931_aws279-B3
  article-title: Idebenone treatment in Leber's hereditary optic neuropathy
  publication-title: Brain
  doi: 10.1093/brain/awr180
  contributor:
    fullname: Carelli
– volume: 38
  start-page: 1495
  year: 1998
  ident: key 20170405101931_aws279-B7
  article-title: Leber hereditary optic neuropathy: respiratory chain dysfunction and degeneration of the optic nerve
  publication-title: Vision Res
  doi: 10.1016/S0042-6989(97)00444-6
  contributor:
    fullname: Howell
– volume: 160
  start-page: 183
  year: 1998
  ident: key 20170405101931_aws279-B2
  article-title: Leber's hereditary optic neuropathy (LHON) with 14484/ND6 mutation in a North African patient
  publication-title: J Neurol Sci
  doi: 10.1016/S0022-510X(98)00239-1
  contributor:
    fullname: Carelli
– volume: 340
  start-page: 368
  year: 1992
  ident: key 20170405101931_aws279-B9
  article-title: Remission of Leber's hereditary optic neuropathy with idebenone
  publication-title: Lancet
  doi: 10.1016/0140-6736(92)91442-B
  contributor:
    fullname: Mashima
– volume: 6
  start-page: e17963
  year: 2011
  ident: key 20170405101931_aws279-B6
  article-title: NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0017963
  contributor:
    fullname: Haefeli
– volume: 134
  start-page: 2677
  year: 2011
  ident: key 20170405101931_aws279-B8
  article-title: A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy
  publication-title: Brain
  doi: 10.1093/brain/awr170
  contributor:
    fullname: Klopstock
– volume: 32
  start-page: 54
  year: 2012
  ident: key 20170405101931_aws279-B11
  article-title: Is leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case
  publication-title: J Neuroophthalmol
  doi: 10.1097/WNO.0b013e318241da45
  contributor:
    fullname: Sabet-Peyman
– volume: 20
  start-page: 166
  year: 2000
  ident: key 20170405101931_aws279-B10
  article-title: Do idebenone and vitamin therapy shorten the time to achieve visual recovery in Leber hereditary optic neuropathy?
  publication-title: J Neuroophthalmol
  doi: 10.1097/00041327-200020030-00006
  contributor:
    fullname: Mashima
SSID ssj0014326
Score 2.5109413
SourceID pubmedcentral
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage e230
SubjectTerms Adolescent
Adult
Aged
Cohort Studies
Double-Blind Method
Female
Follow-Up Studies
Humans
Letters to the Editor
Male
Middle Aged
Optic Atrophy, Hereditary, Leber - drug therapy
Optic Atrophy, Hereditary, Leber - epidemiology
Optic Atrophy, Hereditary, Leber - physiopathology
Time Factors
Treatment Outcome
Ubiquinone - analogs & derivatives
Ubiquinone - pharmacology
Ubiquinone - therapeutic use
Visual Acuity - drug effects
Visual Acuity - physiology
Young Adult
Title Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy
URI https://www.ncbi.nlm.nih.gov/pubmed/23388409
https://pubmed.ncbi.nlm.nih.gov/PMC3572931
Volume 136
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbhMxELZCKyEuqJSfhgLyAU7I6Wb9s_aRVLQVEMQhiPQUeb1eNVKVRMlGSJx4CqS-Xp-Esb1xdiGHwsXaOOtk1_N5PB6Pv0HotWYWFGOWEGNKn8JMwJCygqTK2rxgkmufM3L4WVx8ZR_GfNzp_GpELa2rvGd-7DxX8j9ShTqQqzsl-w-SjT8KFXAN8oUSJAzlnWTswtedmNzgrPf6t4HjIVLDU0IU0IewzPf8IJ_gerkJcVArsBSXMH9VLnhuvnDsrZ7h0iUqbm_4ulQSO_N_BKeCzGTDqfDxer4AqzKo2lEvStX67LFvz2PN5Zp801MyDG7YL7F-4DbwB6dmcx5n0Gu6J1yqiBjqsVG5gkgV2GV7NmhZJhICtoZoqeFAhFLjLW0oVZvWWze29fEv5R-IsfKld6mc6e-rNOSpabNs_zH7xZjEsBtPJ779JLS-h_ahpE5zno9j6BCYmD6NX3y1-kAFtD7xrU9C65apE-2bduxtw5gZHaCH9SoEvwuQeoQ6dnaI7g_rOIvH6LKBLDwvMSALR2ThgCxXH5GFpzPskXX782aFt5jCHlN4i6knaHT2fnR6QeokHMSwTFTE5IlljEvBKWN5YXSpylRLsK36MIxtmVnWz2WRMgODnqtS8QLmz0QLQ3VSFvQp2nOPcYSw7qcmUxzsSaWZ5m6pYhNtrFFFaTMtu-jNprsmi0C1MtkllC56Frow3pVSKp2joouyVufGGxyHevub2fTKc6lTDqtL2n9-x_8-Rg-2IH-B9qrl2r4Eq7TKX3mI_AYeNJC8
link.rule.ids 230,315,783,787,888,27936,27937
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Persistence+of+the+treatment+effect+of+idebenone+in+Leber%E2%80%99s+hereditary+optic+neuropathy&rft.jtitle=Brain+%28London%2C+England+%3A+1878%29&rft.au=Klopstock%2C+T.&rft.au=Metz%2C+G.&rft.au=Yu-Wai-Man%2C+P.&rft.au=B%C3%BCchner%2C+B.&rft.date=2013-02-01&rft.issn=0006-8950&rft.eissn=1460-2156&rft.volume=136&rft.issue=2&rft.spage=e230&rft.epage=e230&rft_id=info:doi/10.1093%2Fbrain%2Faws279&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_brain_aws279
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-8950&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-8950&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-8950&client=summon