REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer

• Published in: Scientific reports Vol. 7; no. 1; p. 42795
• Main Authors: Chang, Yi-Ting, Lin, Tzu-Ping, Campbell, Mel, Pan, Chin-Chen, Lee, Shu-Hui, Lee, Hsin-Chen, Yang, Muh-Hwa, Kung, Hsing-Jien, Chang, Pei-Ching
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.03.2017; Nature Publishing Group
• Subjects: 13/106; 13/31; 14/63; 45/77; 45/90; 631/67/589/466; 631/67/71; 692/4025/1752; 82/51; Humanities and Social Sciences; multidisciplinary; Science

Castration-resistance prostate cancer (CRPC), also known as hormone-refractory prostate cancer (HRPC), requires immediate attention since it is not only resistant to androgen ablation, chemo- and radiotherapy, but also highly metastatic. Increasing evidence suggests that enrichment of neuroendocrine...