Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis

• Published in: Nature structural & molecular biology Vol. 28; no. 12; pp. 1038 - 1049
• Main Authors: Wiener, David, Antebi, Yaron, Schwartz, Schraga
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2021; Nature Publishing Group
• Subjects: 13; 14/35; 14/63; 38; 38/47; 38/77; 38/91; 631/114/2163; 631/337/1645/2020; Adenosine - chemistry; Biochemistry; Biodegradation; Biological Microscopy; Biomedical and Life Sciences; Chemical properties; Cytoplasm; Decomposition (Chemistry); Decoupling; Degradation; Eukaryotes; Exoribonucleases - metabolism; Gene expression; Gene Expression - genetics; Genetic aspects; Life Sciences; Localization; Meiosis; Meiosis - genetics; Membrane Biology; Messenger RNA; Physiological aspects; Poly A - chemistry; Polyadenine; Polyadenylation; Protein Structure; Ribonucleic acid; RNA; RNA Stability - genetics; RNA, Fungal - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - metabolism; Structure; Transcription; Yeast; Yeast fungi; Israel

Nascent messenger RNA is endowed with a poly(A) tail that is subject to gradual deadenylation and subsequent degradation in the cytoplasm. Deadenylation and degradation rates are typically correlated, rendering it difficult to dissect the determinants governing each of these processes and the mechan...