YAP1 preserves tubular mitochondrial quality control to mitigate diabetic kidney disease

• Published in: Redox biology Vol. 78; p. 103435
• Main Authors: Ye, Siyang, Zhang, Meng, Zheng, Xunhua, Li, Suchun, Fan, Yuting, Wang, Yiqin, Peng, Huajing, Chen, Sixiu, Yang, Jiayi, Tan, Li, Zhang, Manhuai, Xie, Peichen, Li, Xiaoyan, Luo, Ning, Wang, Zhipeng, Jin, Leigang, Wu, Xiaoping, Pan, Yong, Fan, Jinjin, Zhou, Yi, Tang, Sydney C.W., Li, Bin, Chen, Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2024; Elsevier
• Subjects: Animals; Chemokine; Diabetic kidney disease; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Hippo signaling pathway; Humans; Kidney Tubules - metabolism; Kidney Tubules - pathology; Macrophage; Male; Mice; Mitochondria; Mitochondria - metabolism; Mitophagy; Research Paper; YAP-Signaling Proteins - metabolism; Yes-associated protein 1; Chemokine; Mitochondria; Hippo signaling pathway; Yes-associated protein 1; Diabetic kidney disease; Macrophage

Renal tubule cells act as a primary site of injury in diabetic kidney disease (DKD), with dysfunctional mitochondrial quality control (MQC) closely associated with progressive kidney dysfunction in this context. Our investigation delves into the observed inactivation of yes-associated protein 1 (YAP...