The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

• Published in: Nature immunology Vol. 14; no. 11; pp. 1155 - 1165
• Main Authors: Man, Kevin, Miasari, Maria, Shi, Wei, Xin, Annie, Henstridge, Darren C, Preston, Simon, Pellegrini, Marc, Belz, Gabrielle T, Smyth, Gordon K, Febbraio, Mark A, Nutt, Stephen L, Kallies, Axel
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2013; Nature Publishing Group
• Subjects: 631/250/248; 631/250/2502/248; Animals; Biomedicine; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - virology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - virology; Cell Differentiation; Cell Proliferation; Clone Cells; Gene Expression Regulation; Genetic aspects; Glucose metabolism; Humans; Immunology; Infectious Diseases; Influenza A Virus, H3N2 Subtype - immunology; Interferon Regulatory Factors - genetics; Interferon Regulatory Factors - immunology; Interferon Regulatory Factors - metabolism; Mice; Mice, Transgenic; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - metabolism; Orthomyxoviridae Infections - virology; Physiological aspects; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Receptors, Antigen, T-Cell - metabolism; T cells; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; T-Lymphocyte Subsets - virology; Transcription factors; Transcription, Genetic; Australia

Clonal expansion of cytotoxic T lymphocytes entails profound energetic demands. Kallies and colleagues show that the transcription factor IRF4 is critical for the metabolic reprogramming, survival and effector function of these cells during clonal expansion. During immune responses, T cells are subj...