DNA damage checkpoints in stem cells, ageing and cancer

• Published in: Nature reviews. Molecular cell biology Vol. 13; no. 9; pp. 579 - 590
• Main Authors: Sperka, Tobias, Wang, Jianwei, Rudolph, K. Lenhard
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2012; Nature Publishing Group
• Subjects: 631/136/532/2118; 631/337/1427/2567; 67; 692/420/755; Aging; Animals; Apoptosis; Ataxia; Biochemistry; Biomedical and Life Sciences; Cancer; Cancer Research; Carcinogenesis; Cell Biology; Cell cycle; Cell Cycle Checkpoints - genetics; Cell Cycle Proteins - genetics; Cell division; Cell Transformation, Neoplastic - genetics; Cellular Senescence - genetics; Chromosomes; Deoxyribonucleic acid; Developmental Biology; DNA; DNA Damage; Genetic aspects; Homeostasis; Humans; Kinases; Life Sciences; Models, Genetic; Physiological aspects; review-article; Risk factors; Stem Cells; Stem Cells - metabolism; Telomerase; Telomere - genetics; Telomere - metabolism; Tissues; Germany

Key Points Checkpoint responses have diverse roles in adult stem cells depending on the genetic context and the level of DNA damage in tissues and stem cells, which increases with age. Thus, the role of checkpoints in stem cells may change during ageing. The activation of checkpoint genes in respons...