Treatment of Peritoneal Surface Malignancies by Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Spain: Results of the National Registry of the Spanish Group of Peritoneal Oncologic Surgery (REGECOP)

• Published in: Journal of clinical medicine Vol. 12; no. 11; p. 3774
• Main Authors: Manzanedo, Israel, Pereira, Fernando, Cascales-Campos, Pedro, Muñoz-Casares, Cristobal, Asensio, Enrique, Torres-Melero, Juan, Prada-Villaverde, Arancha, Caravaca-García, Ibán, Gutiérrez-Calvo, Alberto, Vaqué, Javier, Ortega, Gloria, Titos-García, Alberto, González-Sánchez, Laura, Pérez-Viejo, Estíbalitz, Serrano, Ángel, Martínez-Torres, Beatriz, Regecop Group
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.05.2023; MDPI
• Subjects: Cancer therapies; Chemotherapy; Clinical medicine; Colorectal cancer; cytoreductive surgery; Disease; Gastric cancer; HIPEC; Hospitals; Medical prognosis; Mesothelioma; Morbidity; Mortality; Ovarian cancer; Patients; peritoneal carcinomatosis; Peritoneal Surface Malignancies; Postoperative period; Surgery; Surveillance; Survival analysis; Tumors; Spain; Peritoneal Surface Malignancies; HIPEC; peritoneal carcinomatosis; cytoreductive surgery
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12113774

Treatment of Peritoneal Surface Malignancies (PSM) with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has achieved results never seen before in these patients, which classically have a poor prognosis. The possibility of conducting clinical trials in these diseases is complicated, since some of them are rare, so the analysis of large databases provides very valuable scientific information. The aim of this study is to analyze the global results of the National Registry of the Spanish Group of Peritoneal Oncologic Surgery (REGECOP), whose objective is to register all patients scheduled for HIPEC nationwide. This is a retrospective analysis of the data recorded in the REGECOP from 36 Spanish hospitals from 2001 to 2021. There were 4159 surgical interventions in 3980 patients. 66% are women and 34% are men with a median age of 59 years (range 17-86). 41.5% of the patients were treated for Peritoneal Metastases (PM) of colorectal cancer (CRC); 32.4% were women with ovarian cancer (OC) with PM; 12.8% were treated for pseudomyxoma peritonei (PMP); 6.2% had PM from gastric cancer (GC); 4.9% had PM of non-conventional origin; and, finally, 2.1% of cases were patients diagnosed with peritoneal mesothelioma. The median Peritoneal Cancer Index (PCI) was 9 (0-39), and complete cytoreduction was achieved in 81.7% of the procedures. Severe morbidity (Dindo-Clavien grade III-IV) was observed in 17.7% of surgeries, with 2.1% mortality. Median hospital stay was 11 days (0-259). Median overall survival (OS) was 41 months for CRC patients, 55 months for women with OC, was not reached in PMP patients, was 14 months for GC patients, and 66 months in mesothelioma patients. large databases provide extremely useful data. CRS with HIPEC in referral centers is a safe treatment with encouraging oncologic results in PSM.