Challenges and future directions for representations of functional brain organization
A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity. These p...
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Published in | Nature neuroscience Vol. 23; no. 12; pp. 1484 - 1495 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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01.12.2020
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Abstract | A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity. These patterns have been studied intensively and have been linked to cognition and disease. However, the field is fractionated. Diverging analysis approaches have segregated the community into research silos, limiting the replication and clinical translation of findings. A primary source of this fractionation is the diversity of approaches used to reduce complex brain data into a lower-dimensional set of features for analysis and interpretation, which we refer to as brain representations. In this Primer, we provide an overview of different brain representations, lay out the challenges that have led to the fractionation of the field and that continue to form obstacles for convergence, and propose concrete guidelines to unite the field.
In this Primer article, Bijsterbosch and colleagues provide an accessible discussion of the challenges faced in analytical representations of functional brain organization and provide clear recommendations to unite a fractionated field. |
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AbstractList | A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity. These patterns have been studied intensively and have been linked to cognition and disease. However, the field is fractionated. Diverging analysis approaches have segregated the community into research silos, limiting the replication and clinical translation of findings. A primary source of this fractionation is the diversity of approaches used to reduce complex brain data into a lower-dimensional set of features for analysis and interpretation, which we refer to as brain representations. In this Primer, we provide an overview of different brain representations, lay out the challenges that have led to the fractionation of the field and that continue to form obstacles for convergence, and propose concrete guidelines to unite the field.A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity. These patterns have been studied intensively and have been linked to cognition and disease. However, the field is fractionated. Diverging analysis approaches have segregated the community into research silos, limiting the replication and clinical translation of findings. A primary source of this fractionation is the diversity of approaches used to reduce complex brain data into a lower-dimensional set of features for analysis and interpretation, which we refer to as brain representations. In this Primer, we provide an overview of different brain representations, lay out the challenges that have led to the fractionation of the field and that continue to form obstacles for convergence, and propose concrete guidelines to unite the field. A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity. These patterns have been studied intensively and have been linked to cognition and disease. However, the field is fractionated. Diverging analysis approaches have segregated the community into research silos, limiting the replication and clinical translation of findings. A primary source of this fractionation is the diversity of approaches used to reduce complex brain data into a lower-dimensional set of features for analysis and interpretation, which we refer to as brain representations. In this Primer, we provide an overview of different brain representations, lay out the challenges that have led to the fractionation of the field and that continue to form obstacles for convergence, and propose concrete guidelines to unite the field. In this Primer article, Bijsterbosch and colleagues provide an accessible discussion of the challenges faced in analytical representations of functional brain organization and provide clear recommendations to unite a fractionated field. A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity. These patterns have been studied intensively and have been linked to cognition and disease. However, the field is fractionated. Diverging analysis approaches have segregated the community into research silos, limiting the replication and clinical translation of findings. A primary source of this fractionation is the diversity of approaches used to reduce complex brain data into a lower-dimensional set of features for analysis and interpretation, which we refer to as brain representations. In this Primer, we provide an overview of different brain representations, lay out the challenges that have led to the fractionation of the field and that continue to form obstacles for convergence, and propose concrete guidelines to unite the field. A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity. These patterns have been studied intensively and have been linked to cognition and disease. However, the field is fractionated. Diverging analysis approaches have segregated the community into research silos, limiting the replication and clinical translation of findings. A primary source of this fractionation is the diversity of approaches used to reduce complex brain data into a lower-dimensional set of features for analysis and interpretation, which we refer to as brain representations. In this Primer, we provide an overview of different brain representations, lay out the challenges that have led to the fractionation of the field and that continue to form obstacles for convergence, and propose concrete guidelines to unite the field. In this Primer article, Bijsterbosch and colleagues provide an accessible discussion of the challenges faced in analytical representations of functional brain organization and provide clear recommendations to unite a fractionated field. |
Audience | Academic |
Author | Woolrich, Mark Duff, Eugene P. Smith, Stephen Jbabdi, Saad Bijsterbosch, Janine Harrison, Samuel J. Beckmann, Christian |
Author_xml | – sequence: 1 givenname: Janine orcidid: 0000-0002-1385-9178 surname: Bijsterbosch fullname: Bijsterbosch, Janine email: Janine.Bijsterbosch@wustl.edu organization: Mallinckrodt Institute of Radiology, Washington University in St Louis, Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital – sequence: 2 givenname: Samuel J. orcidid: 0000-0002-5886-2389 surname: Harrison fullname: Harrison, Samuel J. organization: Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital, Translational Neuromodeling Unit, University of Zurich & ETH Zurich – sequence: 3 givenname: Saad surname: Jbabdi fullname: Jbabdi, Saad organization: Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital – sequence: 4 givenname: Mark surname: Woolrich fullname: Woolrich, Mark organization: Oxford Centre for Human Brain Activity (OHBA), Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Warneford Hospital – sequence: 5 givenname: Christian surname: Beckmann fullname: Beckmann, Christian organization: Donders Institute and Department of Cognitive Neurosciences, Radboud University Medical Centre – sequence: 6 givenname: Stephen orcidid: 0000-0001-8166-069X surname: Smith fullname: Smith, Stephen organization: Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital – sequence: 7 givenname: Eugene P. orcidid: 0000-0001-8795-5472 surname: Duff fullname: Duff, Eugene P. email: eugene.duff@ndcn.ox.ac.uk organization: Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital, Department of Paediatrics, University of Oxford, John Radcliffe Hospital |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33106677$$D View this record in MEDLINE/PubMed |
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Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
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Title | Challenges and future directions for representations of functional brain organization |
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