Comparative Proteomics Reveals a Significant Bias Toward Alternative Protein Isoforms with Conserved Structure and Function - Ezkurdia, Iakes; del Pozo, Angela; Frankish, Adam; Rodriguez, Jose Manuel; Harrow, Jennifer; Ashman, Keith; Valencia, Alfonso; Tress, Michael L. (Molecular biology and evolution, 2012)
Keywords: Alternative Splicing; Amino Acid Sequence; Animals; Annotations; Bias; Catalytic Domain; Cellular structure; Drosophila; Exons; Gene expression; Genes; Genome; Genomes; Humans; Identification methods; Insects; Isoforms; Mass spectrometry; Mass spectroscopy; Mice; Models, Molecular; Molecular Sequence Annotation; Molecular Sequence Data; Nonsense Mediated mRNA Decay; Peptides; Peptides - chemistry; Peptides - genetics; Proteasome Endopeptidase Complex - chemistry; Protein Biosynthesis; Protein Conformation; Protein Interaction Domains and Motifs; Protein Isoforms; Protein structure; Proteins; Proteins - chemistry; Proteins - genetics; Proteins - metabolism; Proteomics; Pseudogenes; Ribonucleoproteins; Rodents; Scientific imaging; Sequence Alignment; Structure-function relationships; Translation; heterogeneous nuclear ribonucleoproteins; NAGNAG splicing; alternative splicing; genome annotation; mutually exclusive exons; shotgun proteomics