Pneumococcal IgA1 protease subverts specific protection by human IgA1

• Published in: Mucosal immunology Vol. 7; no. 2; pp. 249 - 256
• Main Authors: Janoff, E N, Rubins, J B, Fasching, C, Charboneau, D, Rahkola, J T, Plaut, A G, Weiser, J N
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.03.2014
• Subjects: Animals; Disease Models, Animal; Humans; Immunoglobulin A - immunology; Immunoglobulin A - metabolism; Immunoglobulin G - blood; Immunoglobulin G - immunology; Mice; Phagocytosis - immunology; Pneumococcal Infections - immunology; Pneumococcal Infections - metabolism; Serine Endopeptidases - metabolism; Streptococcus pneumoniae - enzymology; Streptococcus pneumoniae - immunology

Bacterial immunoglobulin A1 (IgA1) proteases may sabotage the protective effects of IgA. In vitro, both exogenous and endogenously produced IgA1 protease inhibited phagocytic killing of Streptococcus pneumoniae by capsule-specific IgA1 human monoclonal antibodies (hMAbs) but not IgA2. These IgA1 pro...