Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress

• Published in: The journal of clinical endocrinology and metabolism Vol. 91; no. 12; pp. 4836 - 4841
• Main Authors: Paddon-Jones, Douglas, Sheffield-Moore, Melinda, Cree, Melanie G., Hewlings, Susan J., Aarsland, Asle, Wolfe, Robert R., Ferrando, Arny A.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.12.2006; Endocrine Society
• Subjects: Adult; Atrophy; Bed Rest - adverse effects; Biological and medical sciences; Body Composition; Endocrinopathies; Fundamental and applied biological sciences. Psychology; Humans; Hydrocortisone; Hydrocortisone - administration & dosage; Hydrocortisone - adverse effects; Hydrocortisone - blood; Immobilization; Insulin - blood; Leg; Male; Medical sciences; Motor Activity - physiology; Muscle Proteins - biosynthesis; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Muscular Atrophy - etiology; Muscular Atrophy - metabolism; Muscular Atrophy - pathology; Phenylalanine - blood; Protein biosynthesis; Protein composition; Protein folding; Protein synthesis; Proteins; Sodium succinate; Stress, Physiological - complications; Stress, Physiological - metabolism; Vertebrates: endocrinology; Atrophy; Muscle; Protein synthesis; Endocrinology; Stress; Prolonged

Context: We recently demonstrated that 28-d bed rest in healthy volunteers results in a moderate loss of lean leg mass and strength. Objective: The objective of this study was to quantify changes in muscle protein kinetics, body composition, and strength during a clinical bed rest model reflecting b...