Economic Choices under Simultaneous or Sequential Offers Rely on the Same Neural Circuit

• Published in: The Journal of neuroscience Vol. 42; no. 1; pp. 33 - 43
• Main Authors: Shi, Weikang, Ballesta, Sébastien, Padoa-Schioppa, Camillo
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 05.01.2022
• Subjects: Animals; Choice Behavior - physiology; Circuits; Cortex; Decisions; Economics; Juices; Life Sciences; Macaca mulatta; Male; Monkeys; Neural Pathways - physiology; Neurons - physiology; Neurons and Cognition; Prefrontal Cortex - physiology; Psychology and behavior; Sequences; Variables; Windows (intervals); subjective value; neuroeconomics; orbitofrontal cortex; monkey; decision making
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/JNEUROSCI.1265-21.2021

A series of studies in which monkeys chose between two juices offered in variable amounts identified in the orbitofrontal cortex (OFC) different groups of neurons encoding the value of individual options (offer value), the binary choice outcome (chosen juice), and the chosen value. These variables capture both the input and the output of the choice process, suggesting that the cell groups identified in OFC constitute the building blocks of a decision circuit. Several lines of evidence support this hypothesis. However, in previous experiments offers were presented simultaneously, raising the question of whether current notions generalize to when goods are presented or are examined in sequence. Recently, Ballesta and Padoa-Schioppa (2019) examined OFC activity under sequential offers. An analysis of neuronal responses across time windows revealed that a small number of cell groups encoded specific sequences of variables. These sequences appeared analogous to the variables identified under simultaneous offers, but the correspondence remained tentative. Thus, in the present study, we examined the relation between cell groups found under sequential versus simultaneous offers. We recorded from the OFC while monkeys chose between different juices. Trials with simultaneous and sequential offers were randomly interleaved in each session. We classified cells in each choice modality, and we examined the relation between the two classifications. We found a strong correspondence; in other words, the cell groups measured under simultaneous offers and under sequential offers were one and the same. This result indicates that economic choices under simultaneous or sequential offers rely on the same neural circuit. Research in the past 20 years has shed light on the neuronal underpinnings of economic choices. A large number of results indicates that decisions between goods are formed in a neural circuit within the orbitofrontal cortex. In most previous studies, subjects chose between two goods offered simultaneously. Yet, in daily situations, goods available for choice are often presented or examined in sequence. Here we recorded neuronal activity in the primate orbitofrontal cortex alternating trials under simultaneous and under sequential offers. Our analyses demonstrate that the same neural circuit supports choices in the two modalities. Hence, current notions on the neuronal mechanisms underlying economic decisions generalize to choices under sequential offers.