Identified Seaweed Compound Diphenylmethane Serves as an Efflux Pump Inhibitor in Drug-Resistant Escherichia coli

• Published in: Antibiotics (Basel) Vol. 10; no. 11; p. 1378
• Main Authors: Lu, Wen-Jung, Hsu, Pang-Hung, Chang, Chun-Ju, Su, Cheng-Kuan, Huang, Yan-Jyun, Lin, Hsuan-Ju, Lai, Margaret, Ooi, Gui-Xia, Dai, Jing-Yi, Lin, Hong-Ting Victor
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 10.11.2021; MDPI
• Subjects: Accumulation; Algae; Antibacterial activity; Antibiotic resistance; Antibiotics; Antimicrobial agents; aromatic compounds; Bacteria; Bacterial infections; Cell growth; Chemical compounds; Diphenyl methane; diphenylmethane; Drug resistance; drug transporters; Dyes; E coli; Efflux; efflux pump inhibitors; Erythromycin; Escherichia coli; Ethidium bromide; multidrug resistance; Pharmaceutical industry; Pharmacology; Seaweeds; Toxicity; Toxicity testing; Translocation

Drug efflux pumps are one of the major elements used by antibiotic-resistant bacteria. Efflux pump inhibitors (EPIs) are potential therapeutic agents for adjunctive therapy, which can restore the activity of antibiotics that are no longer effective against pathogens. This study evaluated the seaweed...