Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases

Surgical tumor resection has evolved as a potentially curative therapy for patients with resectable colorectal liver metastases (CRLM). However, disease recurrence is common and the available preoperative stratification strategies are often imprecise to identify the ideal candidates for surgical tre...

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Published inDiagnostics (Basel) Vol. 11; no. 11; p. 1999
Main Authors Loosen, Sven H., Roderburg, Christoph, Alizai, Patrick H., Roeth, Anjali A., Schmitz, Sophia M., Vucur, Mihael, Luedde, Mark, Schöler, David, Paffenholz, Pia, Tacke, Frank, Trautwein, Christian, Luedde, Tom, Neumann, Ulf P., Ulmer, Tom F.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 27.10.2021
MDPI
Subjects
Biomarkers
CA19-9
cancer
CEA
Colorectal cancer
CRC
CRLM
Disease
Hospitals
Laboratories
Liver
liver resection
Metastasis
Patients
Aachen Germany
Switzerland
Germany
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Abstract Surgical tumor resection has evolved as a potentially curative therapy for patients with resectable colorectal liver metastases (CRLM). However, disease recurrence is common and the available preoperative stratification strategies are often imprecise to identify the ideal candidates for surgical treatment, resulting in a postoperative 5-year survival rate below 50%. Data on the prognostic value of CEA, CA19-9 and other common laboratory parameters after CRLM resection are scarce and partly inconclusive. Here, we analyzed the prognostic potential of circulating CEA and CA19-9 in comparison to other standard laboratory markers in resectable CRLM patients. Serum levels of tumor markers and other laboratory parameters were analyzed in 125 patients with CRLM undergoing tumor resection at a tertiary referral center. Results were correlated with clinical data and outcome. Both tumor markers were significantly elevated in CRLM patients compared to healthy controls. Interestingly, elevated levels of CEA, CA19-9 and C-reactive protein (CRP) were associated with an unfavorable prognosis after CRLM resection in Kaplan–Meier curve analysis. However, only CEA and not CA19-9 or CRP serum levels were an independent prognostic marker in multivariate Cox regression analysis. Our data demonstrate that circulating levels of CEA rather than CA19-9 might be a valuable addition to the existing preoperative stratification algorithms to identify patients with a poor prognosis after CRLM resection.
AbstractList Surgical tumor resection has evolved as a potentially curative therapy for patients with resectable colorectal liver metastases (CRLM). However, disease recurrence is common and the available preoperative stratification strategies are often imprecise to identify the ideal candidates for surgical treatment, resulting in a postoperative 5-year survival rate below 50%. Data on the prognostic value of CEA, CA19-9 and other common laboratory parameters after CRLM resection are scarce and partly inconclusive. Here, we analyzed the prognostic potential of circulating CEA and CA19-9 in comparison to other standard laboratory markers in resectable CRLM patients. Serum levels of tumor markers and other laboratory parameters were analyzed in 125 patients with CRLM undergoing tumor resection at a tertiary referral center. Results were correlated with clinical data and outcome. Both tumor markers were significantly elevated in CRLM patients compared to healthy controls. Interestingly, elevated levels of CEA, CA19-9 and C-reactive protein (CRP) were associated with an unfavorable prognosis after CRLM resection in Kaplan–Meier curve analysis. However, only CEA and not CA19-9 or CRP serum levels were an independent prognostic marker in multivariate Cox regression analysis. Our data demonstrate that circulating levels of CEA rather than CA19-9 might be a valuable addition to the existing preoperative stratification algorithms to identify patients with a poor prognosis after CRLM resection.
Author Ulmer, Tom F
Roderburg, Christoph
Tacke, Frank
Loosen, Sven H
Roeth, Anjali A
Alizai, Patrick H
Schmitz, Sophia M
Luedde, Mark
Schöler, David
Vucur, Mihael
Neumann, Ulf P
Luedde, Tom
Trautwein, Christian
Paffenholz, Pia
AuthorAffiliation 6 Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany; ctrautwein@ukaachen.de
2 Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany; palizai@ukaachen.de (P.H.A.); aroeth@ukaachen.de (A.A.R.); sopschmitz@ukaachen.de (S.M.S.); uneumann@ukaachen.de (U.P.N.); fulmer@ukaachen.de (T.F.U.)
4 Department of Urology, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany; pia.paffenholz@uk-koeln.de
5 Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; frank.tacke@charite.de
1 Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany; Christoph.Roderburg@med.uni-duesseldorf.de (C.R.); Mihael.Vucur@med.uni-duesseldorf.de (M.V.); david.schoeler@hhu.de (D.S.); Tom.Luedde
AuthorAffiliation_xml – name: 2 Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany; palizai@ukaachen.de (P.H.A.); aroeth@ukaachen.de (A.A.R.); sopschmitz@ukaachen.de (S.M.S.); uneumann@ukaachen.de (U.P.N.); fulmer@ukaachen.de (T.F.U.)
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CitedBy_id crossref_primary_10_1002_jcla_24431
crossref_primary_10_2478_jtim_2022_0004
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Snippet Surgical tumor resection has evolved as a potentially curative therapy for patients with resectable colorectal liver metastases (CRLM). However, disease...
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StartPage 1999
SubjectTerms Biomarkers
CA19-9
cancer
CEA
Colorectal cancer
CRC
CRLM
Disease
Hospitals
Laboratories
Liver
liver resection
Metastasis
Patients
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Title Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases
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Volume 11
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