PD-1 Is an Immune-Inflammatory Potential Biomarker in Cerebrospinal Fluid and Serum of Intractable Epilepsy

• Published in: BioMed research international Vol. 2021; no. 1; p. 7973123
• Main Authors: Tang, Hong, Wang, Xuefeng
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc
• Subjects: Adult; Antiepileptic agents; Apoptosis; Biomarkers; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Care and treatment; CD25 antigen; CD4 antigen; Cerebrospinal fluid; Convulsions & seizures; Diagnosis; Differential diagnosis; Disease; Drug Resistant Epilepsy - blood; Drug Resistant Epilepsy - cerebrospinal fluid; Drug Resistant Epilepsy - immunology; Drug Resistant Epilepsy - pathology; Enzyme-linked immunosorbent assay; Epilepsy; Female; Flow cytometry; Humans; Immunoassays; Inflammation; Lymphocytes; Lymphocytes T; Magnetic resonance imaging; Male; Males; Methods; Patients; PD-1 protein; Prevention; Programmed Cell Death 1 Receptor - blood; Programmed Cell Death 1 Receptor - immunology; Puncture; Risk factors; Seizures; Seizures (Medicine); Signal transduction; Spine; Statistical analysis; Statistical methods; T cell receptors; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; T-Lymphocytes, Regulatory - pathology; China; United States > US

Purpose. Previous studies have demonstrated that immune and inflammatory factors play an important role in recurrent seizures. The PD-1-PD-L pathway plays a central and peripheral immunosuppressive role by regulating multiple signaling pathways during the inflammatory and immunologic processes. This...