A Phytooxysterol, 28-Homobrassinolide Modulates Rat Testicular Steroidogenesis in Normal and Diabetic Rats

Steroidogenesis in testicular cells depends upon the availability of cholesterol within testicular mitochondria besides the activities of 3β-hydroxysteroid dehydrogenase (3β-HSD, 17β-hydroxysteroid dehydrogenase [17b-HSD]), and the tissue levels of steroidogenic acute regulatory protein (StAR), andr...

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Published inReproductive sciences (Thousand Oaks, Calif.) Vol. 20; no. 5; pp. 589 - 596
Main Authors Premalatha, R., Jubendradass, Rajamanickam, Rani, S. Judith Amala, Srikumar, K., Mathur, Premendu Prakash
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.05.2013
Springer International Publishing
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Abstract Steroidogenesis in testicular cells depends upon the availability of cholesterol within testicular mitochondria besides the activities of 3β-hydroxysteroid dehydrogenase (3β-HSD, 17β-hydroxysteroid dehydrogenase [17b-HSD]), and the tissue levels of steroidogenic acute regulatory protein (StAR), androgen-binding protein (ABP), and testosterone (T). Cellular cholesterol biosynthesis is regulated by endogenous oxycholesterols acting through nuclear hormone receptors. Plant oxysterols, such as 28-homobrassinolide (28-HB), available to human through diet, was shown to exhibit antihyperglycemic effect in diabetic male rat. Its role in rat testicular steroidogenesis and lipid peroxidation (LPO) was therefore assessed using normal and streptozotocin-induced diabetic male rats. Administration of 28-HB (333 µg/kg body weight) by oral gavage for 15 consecutive days to experimental rats diminished LPO, increased antioxidant enzyme, 3β-HSD and 17β-HSD activities, and elevated StAR and ABP expression and T level in rat testis. We report that 28-HB induced steroidogenesis in normal and diabetic rat testis.
AbstractList Steroidogenesis in testicular cells depends upon the availability of cholesterol within testicular mitochondria besides the activities of 3β-hydroxysteroid dehydrogenase (3β-HSD, 17β-hydroxysteroid dehydrogenase [17b-HSD]), and the tissue levels of steroidogenic acute regulatory protein (StAR), androgen-binding protein (ABP), and testosterone (T). Cellular cholesterol biosynthesis is regulated by endogenous oxycholesterols acting through nuclear hormone receptors. Plant oxysterols, such as 28-homobrassinolide (28-HB), available to human through diet, was shown to exhibit antihyperglycemic effect in diabetic male rat. Its role in rat testicular steroidogenesis and lipid peroxidation (LPO) was therefore assessed using normal and streptozotocin-induced diabetic male rats. Administration of 28-HB (333 µg/kg body weight) by oral gavage for 15 consecutive days to experimental rats diminished LPO, increased antioxidant enzyme, 3β-HSD and 17β-HSD activities, and elevated StAR and ABP expression and T level in rat testis. We report that 28-HB induced steroidogenesis in normal and diabetic rat testis.
Author Premalatha, R.
Rani, S. Judith Amala
Mathur, Premendu Prakash
Srikumar, K.
Jubendradass, Rajamanickam
AuthorAffiliation 1 Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India
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Issue 5
Keywords phyto-oxysterol
steroidogenesis
28-homobrassinolide
testis
lipid peroxidation
Language English
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Snippet Steroidogenesis in testicular cells depends upon the availability of cholesterol within testicular mitochondria besides the activities of 3β-hydroxysteroid...
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SubjectTerms 17-Hydroxysteroid Dehydrogenases - metabolism
3-Hydroxysteroid Dehydrogenases - metabolism
Androgen-Binding Protein - metabolism
Animals
Cholestanones - pharmacology
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Embryology
Hypoglycemic Agents - pharmacology
Lipid Peroxidation - drug effects
Male
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original
Original Article
Phosphoproteins - metabolism
Rats
Rats, Wistar
Reproductive Medicine
Streptozocin
Testis - drug effects
Testis - metabolism
Testosterone - biosynthesis
Up-Regulation
Title A Phytooxysterol, 28-Homobrassinolide Modulates Rat Testicular Steroidogenesis in Normal and Diabetic Rats
URI https://journals.sagepub.com/doi/full/10.1177/1933719112459241
https://link.springer.com/article/10.1177/1933719112459241
https://www.ncbi.nlm.nih.gov/pubmed/23012313
https://pubmed.ncbi.nlm.nih.gov/PMC3713542
Volume 20
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