A Phytooxysterol, 28-Homobrassinolide Modulates Rat Testicular Steroidogenesis in Normal and Diabetic Rats
Steroidogenesis in testicular cells depends upon the availability of cholesterol within testicular mitochondria besides the activities of 3β-hydroxysteroid dehydrogenase (3β-HSD, 17β-hydroxysteroid dehydrogenase [17b-HSD]), and the tissue levels of steroidogenic acute regulatory protein (StAR), andr...
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| Published in | Reproductive sciences (Thousand Oaks, Calif.) Vol. 20; no. 5; pp. 589 - 596 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Los Angeles, CA
SAGE Publications
01.05.2013
Springer International Publishing |
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| Abstract | Steroidogenesis in testicular cells depends upon the availability of cholesterol within testicular mitochondria besides the activities of 3β-hydroxysteroid dehydrogenase (3β-HSD, 17β-hydroxysteroid dehydrogenase [17b-HSD]), and the tissue levels of steroidogenic acute regulatory protein (StAR), androgen-binding protein (ABP), and testosterone (T). Cellular cholesterol biosynthesis is regulated by endogenous oxycholesterols acting through nuclear hormone receptors. Plant oxysterols, such as 28-homobrassinolide (28-HB), available to human through diet, was shown to exhibit antihyperglycemic effect in diabetic male rat. Its role in rat testicular steroidogenesis and lipid peroxidation (LPO) was therefore assessed using normal and streptozotocin-induced diabetic male rats. Administration of 28-HB (333 µg/kg body weight) by oral gavage for 15 consecutive days to experimental rats diminished LPO, increased antioxidant enzyme, 3β-HSD and 17β-HSD activities, and elevated StAR and ABP expression and T level in rat testis. We report that 28-HB induced steroidogenesis in normal and diabetic rat testis. |
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| AbstractList | Steroidogenesis in testicular cells depends upon the availability of cholesterol within testicular mitochondria besides the activities of 3β-hydroxysteroid dehydrogenase (3β-HSD, 17β-hydroxysteroid dehydrogenase [17b-HSD]), and the tissue levels of steroidogenic acute regulatory protein (StAR), androgen-binding protein (ABP), and testosterone (T). Cellular cholesterol biosynthesis is regulated by endogenous oxycholesterols acting through nuclear hormone receptors. Plant oxysterols, such as 28-homobrassinolide (28-HB), available to human through diet, was shown to exhibit antihyperglycemic effect in diabetic male rat. Its role in rat testicular steroidogenesis and lipid peroxidation (LPO) was therefore assessed using normal and streptozotocin-induced diabetic male rats. Administration of 28-HB (333 µg/kg body weight) by oral gavage for 15 consecutive days to experimental rats diminished LPO, increased antioxidant enzyme, 3β-HSD and 17β-HSD activities, and elevated StAR and ABP expression and T level in rat testis. We report that 28-HB induced steroidogenesis in normal and diabetic rat testis. |
| Author | Premalatha, R. Rani, S. Judith Amala Mathur, Premendu Prakash Srikumar, K. Jubendradass, Rajamanickam |
| AuthorAffiliation | 1 Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India |
| AuthorAffiliation_xml | – name: 1 Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India |
| Author_xml | – sequence: 1 givenname: R. surname: Premalatha fullname: Premalatha, R. – sequence: 2 givenname: Rajamanickam surname: Jubendradass fullname: Jubendradass, Rajamanickam – sequence: 3 givenname: S. Judith Amala surname: Rani fullname: Rani, S. Judith Amala – sequence: 4 givenname: K. surname: Srikumar fullname: Srikumar, K. – sequence: 5 givenname: Premendu Prakash surname: Mathur fullname: Mathur, Premendu Prakash email: ppmathur.bbm@pondiuni.edu.in |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23012313$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_antiox10010017 crossref_primary_10_3390_ijerph19138171 crossref_primary_10_1016_j_jsps_2018_11_015 crossref_primary_10_1016_j_steroids_2020_108756 crossref_primary_10_1016_j_acthis_2019_08_001 crossref_primary_10_1111_and_12171 crossref_primary_10_1016_j_cbi_2017_08_010 crossref_primary_10_1007_s11033_014_3632_5 crossref_primary_10_1007_s11033_016_4052_5 crossref_primary_10_1186_s12906_022_03749_0 crossref_primary_10_1186_1477_7827_11_50 |
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| Keywords | phyto-oxysterol steroidogenesis 28-homobrassinolide testis lipid peroxidation |
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| SubjectTerms | 17-Hydroxysteroid Dehydrogenases - metabolism 3-Hydroxysteroid Dehydrogenases - metabolism Androgen-Binding Protein - metabolism Animals Cholestanones - pharmacology Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Embryology Hypoglycemic Agents - pharmacology Lipid Peroxidation - drug effects Male Medicine & Public Health Obstetrics/Perinatology/Midwifery Original Original Article Phosphoproteins - metabolism Rats Rats, Wistar Reproductive Medicine Streptozocin Testis - drug effects Testis - metabolism Testosterone - biosynthesis Up-Regulation |
| Title | A Phytooxysterol, 28-Homobrassinolide Modulates Rat Testicular Steroidogenesis in Normal and Diabetic Rats |
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