Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 37; pp. E5454 - E5463
• Main Authors: Pageon, Sophie V., Tabarin, Thibault, Yamamoto, Yui, Ma, Yuanqing, Nicovich, Philip R., Bridgeman, John S., Cohnen, André, Benzing, Carola, Gao, Yijun, Crowther, Michael D., Tungatt, Katie, Dolton, Garry, Sewell, Andrew K., Price, David A., Acuto, Oreste, Parton, Robert G., Gooding, J. Justin, Rossy, Jérémie, Rossjohn, Jamie, Gaus, Katharina
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 13.09.2016
• Series: PNAS Plus
• Subjects: Adaptive Immunity - genetics; Animals; Antigens; Antigens - genetics; Antigens - immunology; Biological Sciences; CD3 Complex - immunology; Humans; Immune system; Major Histocompatibility Complex - immunology; Mice; Molecules; Peptides; Peptides - immunology; Phosphorylation; Phosphorylation - immunology; PNAS Plus; Proteins; Receptors, Antigen, T-Cell - immunology; Signal Transduction; Single Molecule Imaging; T cell receptors; TCR triggering; signal transduction; single-molecule localization microscopy

Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal via the associated CD3 complex. How the extracellular antigen recognition even...