Leukocytoclastic Vasculitis Secondary to Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Diseases: A Multicenter Retrospective Cohort Study
Vasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of vasculitis induced by anti-tumor necrosis factor (TNF) therapy in IBD patients. Retrospective assessments were performed using the medical records of adult IBD pa...
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Published in | Journal of clinical medicine Vol. 12; no. 9; p. 3165 |
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Language | English |
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Abstract | Vasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of vasculitis induced by anti-tumor necrosis factor (TNF) therapy in IBD patients.
Retrospective assessments were performed using the medical records of adult IBD patients who underwent outpatient clinical follow-ups between January 2010 and December 2019 in order to identify patients with vasculitis caused by anti-TNF therapy.
There were 2442 patients altogether. Of these, 862 (35%) took anti-TNF medication. Five patients (0.6% of the overall patients;
= 3 (60%) Crohn's disease;
= 2 (40%), ulcerative colitis) were identified as having leukocytoclastic vasculitis (LCV) due to anti-TNF therapy; these patients were white, female, and non-smokers. The mean age of LCV diagnosis was 32.2 years, and the mean IBD duration was 7.2 years. The mean time between the start of biologic therapy and LCV onset was 30.8 months. Most of the patients were using adalimumab (80%;
= 4). All the patients were in remission at the time of the LCV diagnosis, and the vasculitis affected the skin in all cases. Anti-TNF therapy was discontinued in the five abovementioned patients, and the response of LCV to the oral steroids was significantly positive. Remarkably, all five patients experienced complete remission from LCV within 4-12 weeks after starting prednisone therapy, and none of them had LCV recurrence in the follow-up period (a mean duration of 28 months).
LCV is an unusual complication of anti-TNF therapy in the IBD setting. In this context, clinicians should have a high degree of suspicion of LCV in patients who develop an unexplained cutaneous rash. |
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AbstractList | Background: Vasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of vasculitis induced by anti-tumor necrosis factor (TNF) therapy in IBD patients. Methods: Retrospective assessments were performed using the medical records of adult IBD patients who underwent outpatient clinical follow-ups between January 2010 and December 2019 in order to identify patients with vasculitis caused by anti-TNF therapy. Results: There were 2442 patients altogether. Of these, 862 (35%) took anti-TNF medication. Five patients (0.6% of the overall patients;
n
= 3 (60%) Crohn’s disease;
n
= 2 (40%), ulcerative colitis) were identified as having leukocytoclastic vasculitis (LCV) due to anti-TNF therapy; these patients were white, female, and non-smokers. The mean age of LCV diagnosis was 32.2 years, and the mean IBD duration was 7.2 years. The mean time between the start of biologic therapy and LCV onset was 30.8 months. Most of the patients were using adalimumab (80%;
n
= 4). All the patients were in remission at the time of the LCV diagnosis, and the vasculitis affected the skin in all cases. Anti-TNF therapy was discontinued in the five abovementioned patients, and the response of LCV to the oral steroids was significantly positive. Remarkably, all five patients experienced complete remission from LCV within 4–12 weeks after starting prednisone therapy, and none of them had LCV recurrence in the follow-up period (a mean duration of 28 months). Conclusions: LCV is an unusual complication of anti-TNF therapy in the IBD setting. In this context, clinicians should have a high degree of suspicion of LCV in patients who develop an unexplained cutaneous rash. Background: Vasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of vasculitis induced by anti-tumor necrosis factor (TNF) therapy in IBD patients. Methods: Retrospective assessments were performed using the medical records of adult IBD patients who underwent outpatient clinical follow-ups between January 2010 and December 2019 in order to identify patients with vasculitis caused by anti-TNF therapy. Results: There were 2442 patients altogether. Of these, 862 (35%) took anti-TNF medication. Five patients (0.6% of the overall patients; n = 3 (60%) Crohn’s disease; n = 2 (40%), ulcerative colitis) were identified as having leukocytoclastic vasculitis (LCV) due to anti-TNF therapy; these patients were white, female, and non-smokers. The mean age of LCV diagnosis was 32.2 years, and the mean IBD duration was 7.2 years. The mean time between the start of biologic therapy and LCV onset was 30.8 months. Most of the patients were using adalimumab (80%; n = 4). All the patients were in remission at the time of the LCV diagnosis, and the vasculitis affected the skin in all cases. Anti-TNF therapy was discontinued in the five abovementioned patients, and the response of LCV to the oral steroids was significantly positive. Remarkably, all five patients experienced complete remission from LCV within 4–12 weeks after starting prednisone therapy, and none of them had LCV recurrence in the follow-up period (a mean duration of 28 months). Conclusions: LCV is an unusual complication of anti-TNF therapy in the IBD setting. In this context, clinicians should have a high degree of suspicion of LCV in patients who develop an unexplained cutaneous rash. Vasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of vasculitis induced by anti-tumor necrosis factor (TNF) therapy in IBD patients. Retrospective assessments were performed using the medical records of adult IBD patients who underwent outpatient clinical follow-ups between January 2010 and December 2019 in order to identify patients with vasculitis caused by anti-TNF therapy. There were 2442 patients altogether. Of these, 862 (35%) took anti-TNF medication. Five patients (0.6% of the overall patients; = 3 (60%) Crohn's disease; = 2 (40%), ulcerative colitis) were identified as having leukocytoclastic vasculitis (LCV) due to anti-TNF therapy; these patients were white, female, and non-smokers. The mean age of LCV diagnosis was 32.2 years, and the mean IBD duration was 7.2 years. The mean time between the start of biologic therapy and LCV onset was 30.8 months. Most of the patients were using adalimumab (80%; = 4). All the patients were in remission at the time of the LCV diagnosis, and the vasculitis affected the skin in all cases. Anti-TNF therapy was discontinued in the five abovementioned patients, and the response of LCV to the oral steroids was significantly positive. Remarkably, all five patients experienced complete remission from LCV within 4-12 weeks after starting prednisone therapy, and none of them had LCV recurrence in the follow-up period (a mean duration of 28 months). LCV is an unusual complication of anti-TNF therapy in the IBD setting. In this context, clinicians should have a high degree of suspicion of LCV in patients who develop an unexplained cutaneous rash. BACKGROUNDVasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of vasculitis induced by anti-tumor necrosis factor (TNF) therapy in IBD patients. METHODSRetrospective assessments were performed using the medical records of adult IBD patients who underwent outpatient clinical follow-ups between January 2010 and December 2019 in order to identify patients with vasculitis caused by anti-TNF therapy. RESULTSThere were 2442 patients altogether. Of these, 862 (35%) took anti-TNF medication. Five patients (0.6% of the overall patients; n = 3 (60%) Crohn's disease; n = 2 (40%), ulcerative colitis) were identified as having leukocytoclastic vasculitis (LCV) due to anti-TNF therapy; these patients were white, female, and non-smokers. The mean age of LCV diagnosis was 32.2 years, and the mean IBD duration was 7.2 years. The mean time between the start of biologic therapy and LCV onset was 30.8 months. Most of the patients were using adalimumab (80%; n = 4). All the patients were in remission at the time of the LCV diagnosis, and the vasculitis affected the skin in all cases. Anti-TNF therapy was discontinued in the five abovementioned patients, and the response of LCV to the oral steroids was significantly positive. Remarkably, all five patients experienced complete remission from LCV within 4-12 weeks after starting prednisone therapy, and none of them had LCV recurrence in the follow-up period (a mean duration of 28 months). CONCLUSIONSLCV is an unusual complication of anti-TNF therapy in the IBD setting. In this context, clinicians should have a high degree of suspicion of LCV in patients who develop an unexplained cutaneous rash. |
Author | Feitosa, Marley Ribeiro Chebli, Júlio Maria Fonseca Parra, Rogério Serafim Chebli, Liliana Andrade Faria, Francesca Maia Lins Neto, Manoel Alvaro Féres, Omar Medeiros, Terry Rocha de Nigro, Cintia Maura Caseiro Lima Junior, Sérgio Figueiredo de |
AuthorAffiliation | 3 General and Digestive Surgery Service, João de Barros Barreto University Hospital, Belém 66073-000, Brazil 5 Hospital Professor Edmundo Vasconcelos, São Paulo 04038-905, Brazil 4 Department of Gastrointestinal Surgery, Federal University of Alagoas—UFAL, Maceió 57051-090, Brazil 6 Department of Pathology and Forensic Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14048-900, Brazil 1 Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, Brazil 2 Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Center, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil |
AuthorAffiliation_xml | – name: 2 Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Center, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil – name: 4 Department of Gastrointestinal Surgery, Federal University of Alagoas—UFAL, Maceió 57051-090, Brazil – name: 5 Hospital Professor Edmundo Vasconcelos, São Paulo 04038-905, Brazil – name: 1 Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, Brazil – name: 3 General and Digestive Surgery Service, João de Barros Barreto University Hospital, Belém 66073-000, Brazil – name: 6 Department of Pathology and Forensic Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14048-900, Brazil |
Author_xml | – sequence: 1 givenname: Rogério Serafim orcidid: 0000-0002-5566-9284 surname: Parra fullname: Parra, Rogério Serafim organization: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, Brazil – sequence: 2 givenname: Júlio Maria Fonseca surname: Chebli fullname: Chebli, Júlio Maria Fonseca organization: Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Center, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil – sequence: 3 givenname: Liliana Andrade surname: Chebli fullname: Chebli, Liliana Andrade organization: Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Center, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil – sequence: 4 givenname: Sérgio Figueiredo de surname: Lima Junior fullname: Lima Junior, Sérgio Figueiredo de organization: General and Digestive Surgery Service, João de Barros Barreto University Hospital, Belém 66073-000, Brazil – sequence: 5 givenname: Manoel Alvaro surname: Lins Neto fullname: Lins Neto, Manoel Alvaro organization: Department of Gastrointestinal Surgery, Federal University of Alagoas-UFAL, Maceió 57051-090, Brazil – sequence: 6 givenname: Terry Rocha de surname: Medeiros fullname: Medeiros, Terry Rocha de organization: Hospital Professor Edmundo Vasconcelos, São Paulo 04038-905, Brazil – sequence: 7 givenname: Francesca Maia orcidid: 0000-0001-6592-8959 surname: Faria fullname: Faria, Francesca Maia organization: Department of Pathology and Forensic Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14048-900, Brazil – sequence: 8 givenname: Marley Ribeiro surname: Feitosa fullname: Feitosa, Marley Ribeiro organization: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, Brazil – sequence: 9 givenname: Cintia Maura Caseiro surname: Nigro fullname: Nigro, Cintia Maura Caseiro organization: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, Brazil – sequence: 10 givenname: Omar surname: Féres fullname: Féres, Omar organization: Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, Brazil |
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Keywords | ulcerative colitis biologic therapy vasculitis inflammatory bowel disease Crohn’s disease |
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References | Cury (ref_31) 2017; 23 Feitosa (ref_29) 2020; 27 Hindryckx (ref_23) 2017; 11 Azanza (ref_28) 2020; 12 ref_35 ref_33 Butts (ref_11) 2014; 2 Papamichael (ref_1) 2019; 10 Salerno (ref_13) 2009; 41 Moustou (ref_6) 2009; 61 Magro (ref_21) 2017; 11 Sokumbi (ref_3) 2012; 87 Chebli (ref_10) 2018; 155 ref_18 Carlson (ref_17) 2010; 56 Satsangi (ref_20) 2006; 55 Martin (ref_12) 2011; 176 Checkley (ref_4) 2019; 64 Kluger (ref_19) 2009; 27 Ford (ref_26) 2020; 8 Blanco (ref_24) 2014; 41 Rocha (ref_27) 2021; 15 Soria (ref_9) 2007; 86 Andrade (ref_32) 2018; 63 Bezerra (ref_16) 2020; 19 Sy (ref_22) 2016; 45 Jennette (ref_7) 2013; 65 (ref_34) 2006; 73 Akbulut (ref_14) 2008; 14 Nigam (ref_15) 2021; 33 Bernardes (ref_30) 2018; 41 Cuellar (ref_8) 2002; 4 Shavit (ref_25) 2018; 17 ref_5 Bae (ref_2) 2018; 48 |
References_xml | – volume: 55 start-page: 749 year: 2006 ident: ref_20 article-title: The Montreal classification of inflammatory bowel disease: Controversies, consensus, and implications publication-title: Gut doi: 10.1136/gut.2005.082909 contributor: fullname: Satsangi – volume: 23 start-page: E1 year: 2017 ident: ref_31 article-title: Cutaneous Vasculitis in a Patient with Crohn’s Disease Treated with Adalimumab publication-title: Inflamm. Bowel. Dis. doi: 10.1097/MIB.0000000000000982 contributor: fullname: Cury – volume: 73 start-page: 710 year: 2006 ident: ref_34 article-title: Vasculitides induced by TNFalpha antagonists: A study in 39 patients in France publication-title: Jt. Bone Spine – volume: 10 start-page: 2040622319838443 year: 2019 ident: ref_1 article-title: Infliximab in inflammatory bowel disease publication-title: Ther. Adv. Chronic Dis. doi: 10.1177/2040622319838443 contributor: fullname: Papamichael – volume: 19 start-page: e20180072 year: 2020 ident: ref_16 article-title: Early diagnosis and treatment of Leukocytoclastic Vasculitis: Case report publication-title: J. Vasc. Bras. doi: 10.1590/1677-5449.190072 contributor: fullname: Bezerra – ident: ref_33 doi: 10.3390/jcm11030739 – volume: 45 start-page: 475 year: 2016 ident: ref_22 article-title: Vasculitis in patients with inflammatory bowel diseases: A study of 32 patients and systematic review of the literature publication-title: Semin. Arthritis Rheum. doi: 10.1016/j.semarthrit.2015.07.006 contributor: fullname: Sy – ident: ref_35 doi: 10.3390/jcm12072672 – volume: 11 start-page: 203 year: 2017 ident: ref_23 article-title: Disease-related and drug-induced skin manifestations in inflammatory bowel disease publication-title: Expert Rev. Gastroenterol. Hepatol. contributor: fullname: Hindryckx – volume: 41 start-page: 442 year: 2018 ident: ref_30 article-title: Leukocytoclastic vasculitis complicating adalimumab therapy for Crohn’s disease: Report of three cases publication-title: Gastroenterol. Hepatol. doi: 10.1016/j.gastrohep.2017.08.004 contributor: fullname: Bernardes – volume: 11 start-page: 649 year: 2017 ident: ref_21 article-title: Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders publication-title: J. Crohn’s Colitis doi: 10.1093/ecco-jcc/jjx008 contributor: fullname: Magro – volume: 63 start-page: 746 year: 2018 ident: ref_32 article-title: Anti-Tumor Necrosis Factor-α-Induced Dermatological Complications in a Large Cohort of Inflammatory Bowel Disease Patients publication-title: Dig. Dis. Sci. doi: 10.1007/s10620-018-4921-y contributor: fullname: Andrade – ident: ref_18 – volume: 65 start-page: 1 year: 2013 ident: ref_7 article-title: 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides publication-title: Arthritis Rheum. doi: 10.1002/art.37715 contributor: fullname: Jennette – volume: 4 start-page: 55 year: 2002 ident: ref_8 article-title: Drug-induced vasculitis publication-title: Curr. Rheumatol. Rep. doi: 10.1007/s11926-002-0024-y contributor: fullname: Cuellar – volume: 12 start-page: e7912 year: 2020 ident: ref_28 article-title: Leukocytoclastic Vasculitis: An Early Skin Biopsy Makes a Difference publication-title: Cureus contributor: fullname: Azanza – volume: 8 start-page: 2324709620947608 year: 2020 ident: ref_26 article-title: Leukocytoclastic Vasculitis as the Presenting Symptom of Crohn’s Disease in an Adolescent publication-title: J. Investig. Med. High Impact Case Rep. contributor: fullname: Ford – volume: 27 start-page: e15 year: 2020 ident: ref_29 article-title: Cutaneous Vasculitis Associated With Vedolizumab in Ulcerative Colitis publication-title: Inflamm. Bowel Dis. contributor: fullname: Feitosa – volume: 14 start-page: 2448 year: 2008 ident: ref_14 article-title: Ulcerative colitis presenting as leukocytoclastic vasculitis of skin publication-title: World J. Gastroenterol. doi: 10.3748/wjg.14.2448 contributor: fullname: Akbulut – volume: 86 start-page: 242 year: 2007 ident: ref_9 article-title: Autoimmune diseases induced by TNF-targeted therapies: Analysis of 233 cases publication-title: Medicine doi: 10.1097/MD.0b013e3181441a68 contributor: fullname: Soria – volume: 2 start-page: 2050313X14547609 year: 2014 ident: ref_11 article-title: Leukocytoclastic vasculitis in an adolescent with ulcerative colitis: Report of a case and review of the literature publication-title: SAGE Open Med. Case Rep. contributor: fullname: Butts – volume: 61 start-page: 486 year: 2009 ident: ref_6 article-title: Cutaneous side effects of anti-tumor necrosis factor biologic therapy: A clinical review publication-title: J. Am. Acad. Dermatol. doi: 10.1016/j.jaad.2008.10.060 contributor: fullname: Moustou – volume: 15 start-page: 825 year: 2021 ident: ref_27 article-title: Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn’s Disease publication-title: Case Rep. Gastroenterol. doi: 10.1159/000519003 contributor: fullname: Rocha – volume: 64 start-page: 855 year: 2019 ident: ref_4 article-title: Incidence and Management of Infusion Reactions to Infliximab in an Alternate Care Setting publication-title: Dig. Dis. Sci. doi: 10.1007/s10620-018-5319-6 contributor: fullname: Checkley – volume: 56 start-page: 3 year: 2010 ident: ref_17 article-title: The histological assessment of cutaneous vasculitis publication-title: Histopathology doi: 10.1111/j.1365-2559.2009.03443.x contributor: fullname: Carlson – volume: 41 start-page: 2201 year: 2014 ident: ref_24 article-title: Drug-associated cutaneous vasculitis: Study of 239 patients from a single referral center publication-title: J. Rheumatol. doi: 10.3899/jrheum.140390 contributor: fullname: Blanco – volume: 48 start-page: 196 year: 2018 ident: ref_2 article-title: Incidence of psoriasiform diseases secondary to tumour necrosis factor antagonists in patients with inflammatory bowel disease: A nationwide population-based cohort study publication-title: Aliment. Pharmacol. Ther. doi: 10.1111/apt.14822 contributor: fullname: Bae – ident: ref_5 doi: 10.1186/s12876-020-01371-3 – volume: 33 start-page: 346 year: 2021 ident: ref_15 article-title: Systematic review and meta-analysis of dermatological reactions in patients with inflammatory bowel disease treated with anti-tumour necrosis factor therapy publication-title: Eur. J. Gastroenterol. Hepatol. doi: 10.1097/MEG.0000000000001917 contributor: fullname: Nigam – volume: 41 start-page: e42 year: 2009 ident: ref_13 article-title: Ulcerative colitis associated with leukocytoclastic vasculitis of the skin publication-title: Dig. Liver Dis. doi: 10.1016/j.dld.2008.06.018 contributor: fullname: Salerno – volume: 87 start-page: 739 year: 2012 ident: ref_3 article-title: Vasculitis associated with tumor necrosis factor-α inhibitors publication-title: Mayo Clin. Proc. doi: 10.1016/j.mayocp.2012.04.011 contributor: fullname: Sokumbi – volume: 176 start-page: 581 year: 2011 ident: ref_12 article-title: Leucocytoclastic vasculitis in severe ulcerative colitis publication-title: Mil. Med. doi: 10.7205/MILMED-D-10-00409 contributor: fullname: Martin – volume: 155 start-page: 618 year: 2018 ident: ref_10 article-title: An Unusual Cause of Skin Rash in Crohn’s Disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2018.01.061 contributor: fullname: Chebli – volume: 27 start-page: S124 year: 2009 ident: ref_19 article-title: Cutaneous vasculitis and their differential diagnoses publication-title: Clin. Exp. Rheumatol. contributor: fullname: Kluger – volume: 17 start-page: 218 year: 2018 ident: ref_25 article-title: Vasculitis-What Do We Have to Know? A Review of Literature publication-title: Int. J. Low. Extrem. Wounds doi: 10.1177/1534734618804982 contributor: fullname: Shavit |
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Snippet | Vasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of vasculitis induced by... Background: Vasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of... BACKGROUNDVasculitis is an uncommon complication of biologics used to treat inflammatory bowel disease (IBD). This study describes a case series of vasculitis... |
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SubjectTerms | biologic therapy Clinical medicine Cohort analysis Crohn’s disease Inflammatory bowel disease Lupus Remission (Medicine) Tumor necrosis factor-TNF ulcerative colitis vasculitis |
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Title | Leukocytoclastic Vasculitis Secondary to Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Diseases: A Multicenter Retrospective Cohort Study |
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