An in vitro system to study trans-neuronal spread of pseudorabies virus infection

• Published in: Veterinary microbiology Vol. 113; no. 3; pp. 193 - 197
• Main Authors: Ch’ng, T.H., Enquist, L.W.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 31.03.2006; Elsevier Science
• Subjects: Animals; Aujeszky disease; Biological and medical sciences; cell culture; Cell Culture Techniques - methods; Cell Culture Techniques - veterinary; Cell–cell period; central nervous system; Compartmented chambers; cultured cells; disease course; epithelium; Fundamental and applied biological sciences. Psychology; Herpesvirus 1, Suid - metabolism; Herpesvirus 1, Suid - pathogenicity; Herpesvirus 1, Suid - physiology; in vitro studies; infection; latent period; microbial colonization; Microbiology; Microscopy, Confocal - veterinary; Miscellaneous; neurons; Neurons - ultrastructure; Neurons - virology; peripheral nervous system; Pseudorabies; Pseudorabies - pathology; Pseudorabies - virology; Pseudorabies virus; Rat PNS neurons; Rats; Suid alphaherpesvirus 1; Suid herpesvirus 1; swine; viral fusion proteins; virion; Virion - ultrastructure; Virology; Virus Cultivation - methods; Virus Cultivation - veterinary; Virus Replication; Rat PNS neurons; Cell–cell period; Pseudorabies; Compartmented chambers; Microbiology; Rat; Herpesviridae; Alphaherpesvirinae; Rodentia; Infection; Virus; Aujeszky virus; Vertebrata; Aujeszky disease; Mammalia; Neuron; Viral disease; Cell-cell period; Veterinary

The neuronal spread of infection of alpha herpesviruses is controlled by unknown mechanisms. In the natural host, primary infection always leads to invasion of the peripheral nervous system, but rarely results in extensive invasion of the central nervous system. After reactivation of latent infectio...