Interindividual Variation in Metabolism of Soy Isoflavones and Lignans: Influence of Habitual Diet on Equol Production by the Gut Microflora

• Published in: Nutrition and cancer Vol. 36; no. 1; pp. 27 - 32
• Main Authors: Rowland, Ian R., Wiseman, Helen, Sanders, Tom A. B., Adlercreutz, Herman, Bowey, Elizabeth A.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Lawrence Erlbaum Associates, Inc 01.01.2000; Taylor& Francis
• Subjects: administration & dosage; Adult; Biological and medical sciences; blood plasma; Carcinogenesis, carcinogens and anticarcinogens; Chromans; Chromans - metabolism; Chromans - urine; Cross-Over Studies; Diet; Dietary Fats; Dietary Fats - administration & dosage; Dietary Proteins; Dietary Proteins - administration & dosage; Energy Intake; Enterobacteriaceae; Enterobacteriaceae - metabolism; Equol; excretion; experimental diets; Female; Foods and miscellaneous; Fundamental and applied biological sciences. Psychology; General aspects. Body compartment; Genetic Variation; Humans; Intestines; Intestines - microbiology; isoflavones; Isoflavones - administration & dosage; Isoflavones - metabolism; Isoflavones - urine; lignans; Lignans - metabolism; Male; meat analogs; Medical sciences; men; metabolism; Metabolisms and neurohumoral controls; metabolites; microbiology; nutrient intake; protein concentrates; soy protein; Soybean Proteins; Soybean Proteins - administration & dosage; Soybean Proteins - metabolism; soybeans; Tumors; urine; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Human; Correlation; Variations; Soybean; Metabolism; Carcinogenesis; Diet; Flora; Interindividual comparison; Risk factor; Bacteria; Lignan; Actinomycetes; Microbacterium

The soy isoflavones, daidzein and genistein, and the lignans, matairesinol and secoisolariciresinol, are phytoestrogens metabolized extensively by the intestinal microflora. Considerable important evidence is already available that shows extensive interindividual variation in isoflavone metabolism,...