Effect of n-3 long-chain polyunsaturated fatty acid intake on the eicosanoid profile in individuals with obesity and overweight: a systematic review and meta-analysis of clinical trials

Dietary n-3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role and maintaining physiological homeostasis in obesity. The primary objective of this systematic review was to evaluate the effect of n-3 PUFAs...

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Published inJournal of nutritional science (Cambridge) Vol. 10; p. e53
Main Authors Schweitzer, Guilherme R. B., Rios, Isabela N. M. S., Gonçalves, Vivian S. S., Magalhães, Kelly G., Pizato, Nathalia
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 2021
Subjects
Arachidonic Acid - blood
Bias
Chronic illnesses
Clinical trials
Clinical Trials as Topic
Eicosanoids
Eicosanoids - blood
Enzymes
Fatty acids
Fatty Acids, Omega-3 - therapeutic use
Gastrointestinal surgery
Human and Clinical Nutrition
Humans
Inflammation
Insulin resistance
Meta-analysis
Metabolism
Metabolites
n-3 PUFA
Obesity
Obesity - blood
Overweight
Overweight - blood
Review
Systematic review
Eicosanoids
Obesity
Systematic review
Inflammation
n-3 PUFA
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Abstract Dietary n-3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role and maintaining physiological homeostasis in obesity. The primary objective of this systematic review was to evaluate the effect of n-3 PUFAs intake on the eicosanoid profile of people with obesity and overweight. The search strategy on Embase, Scopus, PubMed, Web of Science, Cochrane Library, Google Scholar and ProQuest was undertaken until November 2019 and updated January 2021. The effect size of n-3 PUFAs on prostaglandins was estimated by Glass's, type 1 in a random-effect model for the meta-analysis. Seven clinical trials met the eligible criteria and a total of 610 subjects were included in this systematic review, and four of seven studies were included in meta-analysis. The intake of n-3 PUFAs promoted an overall reduction in serum pro-inflammatory eicosanoids. Additionally, n-3 PUFAs intake significantly decreased the arachidonic acid COX-derived PG eicosanoid group levels (Glass's Δ −0⋅35; CI −0⋅62, −0⋅07, I2 31⋅48). Subgroup analyses showed a higher effect on periods up to 8 weeks (Glass's Δ −0⋅51; CI −0⋅76, −0⋅27) and doses higher than 0⋅5 g of n-3 PUFAs (Glass's Δ −0⋅46; CI −0⋅72, −0⋅27). Dietary n-3 PUFAs intake contributes to reduce pro-inflammatory eicosanoids of people with obesity and overweight. Subgroup's analysis showed that n-3 PUFAs can reduce the overall arachidonic acid COX-derived PG when adequate dose and period are matched.
AbstractList Dietary n-3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role and maintaining physiological homeostasis in obesity. The primary objective of this systematic review was to evaluate the effect of n-3 PUFAs intake on the eicosanoid profile of people with obesity and overweight. The search strategy on Embase, Scopus, PubMed, Web of Science, Cochrane Library, Google Scholar and ProQuest was undertaken until November 2019 and updated January 2021. The effect size of n-3 PUFAs on prostaglandins was estimated by Glass's, type 1 in a random-effect model for the meta-analysis. Seven clinical trials met the eligible criteria and a total of 610 subjects were included in this systematic review, and four of seven studies were included in meta-analysis. The intake of n-3 PUFAs promoted an overall reduction in serum pro-inflammatory eicosanoids. Additionally, n-3 PUFAs intake significantly decreased the arachidonic acid COX-derived PG eicosanoid group levels (Glass's Δ −0⋅35; CI −0⋅62, −0⋅07, I2 31⋅48). Subgroup analyses showed a higher effect on periods up to 8 weeks (Glass's Δ −0⋅51; CI −0⋅76, −0⋅27) and doses higher than 0⋅5 g of n-3 PUFAs (Glass's Δ −0⋅46; CI −0⋅72, −0⋅27). Dietary n-3 PUFAs intake contributes to reduce pro-inflammatory eicosanoids of people with obesity and overweight. Subgroup's analysis showed that n-3 PUFAs can reduce the overall arachidonic acid COX-derived PG when adequate dose and period are matched.
Dietary -3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role and maintaining physiological homeostasis in obesity. The primary objective of this systematic review was to evaluate the effect of -3 PUFAs intake on the eicosanoid profile of people with obesity and overweight. The search strategy on Embase, Scopus, PubMed, Web of Science, Cochrane Library, Google Scholar and ProQuest was undertaken until November 2019 and updated January 2021. The effect size of -3 PUFAs on prostaglandins was estimated by Glass's, type 1 in a random-effect model for the meta-analysis. Seven clinical trials met the eligible criteria and a total of 610 subjects were included in this systematic review, and four of seven studies were included in meta-analysis. The intake of -3 PUFAs promoted an overall reduction in serum pro-inflammatory eicosanoids. Additionally, -3 PUFAs intake significantly decreased the arachidonic acid COX-derived PG eicosanoid group levels (Glass's Δ -0⋅35; CI -0⋅62, -0⋅07, 31⋅48). Subgroup analyses showed a higher effect on periods up to 8 weeks (Glass's Δ -0⋅51; CI -0⋅76, -0⋅27) and doses higher than 0⋅5 g of -3 PUFAs (Glass's Δ -0⋅46; CI -0⋅72, -0⋅27). Dietary -3 PUFAs intake contributes to reduce pro-inflammatory eicosanoids of people with obesity and overweight. Subgroup's analysis showed that -3 PUFAs can reduce the overall arachidonic acid COX-derived PG when adequate dose and period are matched.
Dietary n -3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role and maintaining physiological homeostasis in obesity. The primary objective of this systematic review was to evaluate the effect of n -3 PUFAs intake on the eicosanoid profile of people with obesity and overweight. The search strategy on Embase, Scopus, PubMed, Web of Science, Cochrane Library, Google Scholar and ProQuest was undertaken until November 2019 and updated January 2021. The effect size of n -3 PUFAs on prostaglandins was estimated by Glass's, type 1 in a random-effect model for the meta-analysis. Seven clinical trials met the eligible criteria and a total of 610 subjects were included in this systematic review, and four of seven studies were included in meta-analysis. The intake of n -3 PUFAs promoted an overall reduction in serum pro-inflammatory eicosanoids. Additionally, n -3 PUFAs intake significantly decreased the arachidonic acid COX-derived PG eicosanoid group levels (Glass's Δ −0⋅35; CI −0⋅62, −0⋅07, I 2 31⋅48). Subgroup analyses showed a higher effect on periods up to 8 weeks (Glass's Δ −0⋅51; CI −0⋅76, −0⋅27) and doses higher than 0⋅5 g of n -3 PUFAs (Glass's Δ −0⋅46; CI −0⋅72, −0⋅27). Dietary n -3 PUFAs intake contributes to reduce pro-inflammatory eicosanoids of people with obesity and overweight. Subgroup's analysis showed that n -3 PUFAs can reduce the overall arachidonic acid COX-derived PG when adequate dose and period are matched.
Abstract Dietary n -3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role and maintaining physiological homeostasis in obesity. The primary objective of this systematic review was to evaluate the effect of n -3 PUFAs intake on the eicosanoid profile of people with obesity and overweight. The search strategy on Embase, Scopus, PubMed, Web of Science, Cochrane Library, Google Scholar and ProQuest was undertaken until November 2019 and updated January 2021. The effect size of n -3 PUFAs on prostaglandins was estimated by Glass's, type 1 in a random-effect model for the meta-analysis. Seven clinical trials met the eligible criteria and a total of 610 subjects were included in this systematic review, and four of seven studies were included in meta-analysis. The intake of n -3 PUFAs promoted an overall reduction in serum pro-inflammatory eicosanoids. Additionally, n -3 PUFAs intake significantly decreased the arachidonic acid COX-derived PG eicosanoid group levels (Glass's Δ −0⋅35; CI −0⋅62, −0⋅07, I 2 31⋅48). Subgroup analyses showed a higher effect on periods up to 8 weeks (Glass's Δ −0⋅51; CI −0⋅76, −0⋅27) and doses higher than 0⋅5 g of n -3 PUFAs (Glass's Δ −0⋅46; CI −0⋅72, −0⋅27). Dietary n -3 PUFAs intake contributes to reduce pro-inflammatory eicosanoids of people with obesity and overweight. Subgroup's analysis showed that n -3 PUFAs can reduce the overall arachidonic acid COX-derived PG when adequate dose and period are matched.
ArticleNumber e53
Author Schweitzer, Guilherme R. B.
Pizato, Nathalia
Magalhães, Kelly G.
Gonçalves, Vivian S. S.
Rios, Isabela N. M. S.
AuthorAffiliation 3 Laboratory of Immunology and Inflammation, Department of Cellular Biology, Institute of Biology, University of Brasília , Brasília , Brazil
2 Graduate Program in Public Health, University of Brasilia , Brasília , Brazil
1 Graduate Program in Human Nutrition, Department of Nutrition, University of Brasilia , Brasilia , Brazil
AuthorAffiliation_xml – name: 3 Laboratory of Immunology and Inflammation, Department of Cellular Biology, Institute of Biology, University of Brasília , Brasília , Brazil
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crossref_primary_10_1186_s43162_023_00265_6
crossref_primary_10_1002_jev2_12382
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Keywords Eicosanoids
Obesity
Systematic review
Inflammation
n-3 PUFA
Language English
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  doi: 10.1093/jn/133.5.1409
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Snippet Dietary n-3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role...
Dietary -3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role...
Abstract Dietary n -3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical...
Dietary n -3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role...
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SubjectTerms Arachidonic Acid - blood
Bias
Chronic illnesses
Clinical trials
Clinical Trials as Topic
Eicosanoids
Eicosanoids - blood
Enzymes
Fatty acids
Fatty Acids, Omega-3 - therapeutic use
Gastrointestinal surgery
Human and Clinical Nutrition
Humans
Inflammation
Insulin resistance
Meta-analysis
Metabolism
Metabolites
n-3 PUFA
Obesity
Obesity - blood
Overweight
Overweight - blood
Review
Systematic review
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Title Effect of n-3 long-chain polyunsaturated fatty acid intake on the eicosanoid profile in individuals with obesity and overweight: a systematic review and meta-analysis of clinical trials
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