The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans

• Published in: Genes & development Vol. 22; no. 18; pp. 2520 - 2534
• Main Authors: Ow, Maria C, Martinez, Natalia J, Olsen, Philip H, Silverman, Howard S, Barrasa, M Inmaculada, Conradt, Barbara, Walhout, Albertha J M, Ambros, Victor
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 15.09.2008
• Subjects: Amino Acid Sequence; Animals; Binding Sites; Caenorhabditis elegans; Caenorhabditis elegans - embryology; Caenorhabditis elegans - genetics; Gene Expression Regulation, Developmental; Genes, Helminth; MicroRNAs - genetics; Molecular Sequence Data; Research Paper; RNA Interference; Sequence Homology, Amino Acid; Transcription Factors - chemistry; Transcription Factors - metabolism; Transcription Factors - physiology

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally via antisense base-pairing. Although miRNAs are involved in a variety of important biological functions, little is known about their transcriptional regulation. Using yeast one-hybrid assays, we identifi...