DHEA and DHEA-S response to acute psychosocial stress in healthy men and women

• Published in: Biological psychology Vol. 90; no. 2; pp. 143 - 149
• Main Authors: Lennartsson, Anna-Karin, Kushnir, Mark M., Bergquist, Jonas, Jonsdottir, Ingibjörg H.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.2012; Elsevier
• Subjects: Acute stress; Adrenocorticotropic Hormone - blood; adrenocorticotropin; Adult; age-related-changes; Behavioral psychophysiology; Biological and medical sciences; Blood Pressure - physiology; cortisol; Dehydroepiandrosterone - blood; Dehydroepiandrosterone Sulfate - blood; dehydroepiandrosterone-sulfate; DHEA; DHEA-S; Female; Fundamental and applied biological sciences. Psychology; Heart Rate - physiology; Humans; Hydrocortisone - blood; Male; mass-spectrometry assay; Men and women; Neurosciences; Neurovetenskaper; pituitary-adrenal axis; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psykiatri; Radioimmunoassay; serum; Sex Characteristics; sex-differences; Stress, Psychological - blood; Stress, Psychological - physiopathology; testosterone; Trier Social Stress Test; DHEA; Trier Social Stress Test; Acute stress; DHEA-S; Men and women; Human; Healthy subject; Acute; Male; Psychosocial factor; Stress; Dehydroepiandrosterone; Female; Woman
• DOI: 10.1016/j.biopsycho.2012.03.003
• ISSN: 0301-0511; 1873-6246

► DHEA and DHEA-S increase in response to acute psychosocial stress. ► Large inter-individual variation in magnitude of the response was seen. ► No differences in magnitude of response were seen between men and women. ► DHEA response was positively associated with ACTH, cortisol and heart rate response. ► Secretion of DHEA and DHEA-S during acute stress seems to decrease with age. This study investigates the effect of acute psychosocial stress on serum concentrations of DHEA and DHEA-S in healthy men and women. Twenty men and 19 women (age 30–50 years) underwent Trier Social Stress Test (TSST). Physiological measurements were performed before, directly after the stress test and after 30mins of recovery. In both men and women, significantly elevated DHEA and DHEA-S levels were observed in response to the stressor. There was a large inter-individual variation in the magnitude of the response, especially for DHEA but no statistical difference between men and women. Magnitude of the change in the levels of DHEA was found to be positively associated with the magnitude of the changes in ACTH, cortisol and heart rate. Furthermore, the results of this study suggest that the capacity to secrete DHEA and DHEA-S during acute psychosocial stress declines with age.