Pharmacokinetics, Pharmacodynamics and Safety of Febuxostat, a Non-Purine Selective Inhibitor of Xanthine Oxidase, in a Dose Escalation Study in Healthy Subjects - Khosravan, Reza; Grabowski, Brian A; Wu, Jing-Tao; Joseph-Ridge, Nancy; Vernillet, Laurent (Clinical pharmacokinetics, 2006)
Keywords: Administration, Oral; Adolescent; Adult; Biological and medical sciences; Dose-Response Relationship, Drug; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - pharmacokinetics; Febuxostat; Female; General and cellular metabolism. Vitamins; Gout Suppressants - administration & dosage; Gout Suppressants - adverse effects; Gout Suppressants - pharmacokinetics; Humans; Hypoxanthine - blood; Hypoxanthine - urine; Male; Medical sciences; Models, Biological; Pharmacology. Drug treatments; Thiazoles - administration & dosage; Thiazoles - adverse effects; Thiazoles - pharmacokinetics; Uric Acid - blood; Uric Acid - urine; Xanthine - blood; Xanthine - urine; Xanthine Oxidase - antagonists & inhibitors; Human; Pharmacodynamics; Hypouricemic agent; Healthy subject; Enzyme; Febuxostat; Toxicity; Enzyme inhibitor; Xanthine dehydrogenase; Posology; Dose activity relation; Increasing dose; Xanthine oxidase; Oxidoreductases; Pharmacokinetics