Estrogen receptor β gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women

• Published in: Bone (New York, N.Y.) Vol. 31; no. 2; pp. 276 - 281
• Main Authors: Lau, H.H.L, Ho, A.Y.Y, Luk, K.D.K, Kung, A.W.C
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2002; Elsevier Science
• Subjects: Adult; Aged; Analysis of Variance; Biological and medical sciences; Bone Density - genetics; Bone mineral density (BMD); Estrogen receptor (ER); Estrogen Receptor beta; Female; Fundamental and applied biological sciences. Psychology; Genetic Markers - genetics; Hong Kong; Humans; Middle Aged; Polymorphism, Genetic - genetics; Postmenopause - genetics; Premenopause - genetics; Receptors, Estrogen - genetics; Skeleton and joints; Southern Chinese women; Terminal Repeat Sequences - genetics; Vertebrates: osteoarticular system, musculoskeletal system; Hong Kong; Bone mineral density (BMD); Southern Chinese women; Estrogen receptor (ER); Human; Biochemical analysis; Premenopause; Estrogen; Genotype; Density; Ovarian hormone; Osteoarticular system; Estrogen receptor β; Gene; Hormonal regulation; Postmenopause; Genetics; Adult; Chinese; Female; Bone; Sex steroid hormone; Molecular biology; Elderly; Polymorphism

Bone mineral density (BMD), the main determining risk factor for osteoporotic fractures, has a strong genetic component. Estrogen and its receptors play a critical role in both skeletal maturity and bone loss. We investigated the association between dinucleotide (cytosine-adenine; CA) repeat polymor...