Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

• Published in: eLife Vol. 13
• Main Authors: Perofsky, Amanda C, Huddleston, John, Hansen, Chelsea L, Barnes, John R, Rowe, Thomas, Xu, Xiyan, Kondor, Rebecca, Wentworth, David E, Lewis, Nicola, Whittaker, Lynne, Ermetal, Burcu, Harvey, Ruth, Galiano, Monica, Daniels, Rodney Stuart, McCauley, John W, Fujisaki, Seiichiro, Nakamura, Kazuya, Kishida, Noriko, Watanabe, Shinji, Hasegawa, Hideki, Sullivan, Sheena G, Barr, Ian G, Subbarao, Kanta, Krammer, Florian, Bedford, Trevor, Viboud, Cécile
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 25.09.2024; eLife Sciences Publications, Ltd
• Subjects: Adolescent; Adult; Antigenic drift; Antigenic Drift and Shift - genetics; Antigenic variation; Antigens, Viral - genetics; Antigens, Viral - immunology; Child; Child, Preschool; Dominance; Epidemics; Epidemiology; Epidemiology and Global Health; Epitopes; Evolution, Molecular; Exo-a-sialidase; Genetic distance; H3N2; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; Humans; Influenza A; Influenza A Virus, H3N2 Subtype - genetics; Influenza A Virus, H3N2 Subtype - immunology; influenza virus; Influenza, Human - epidemiology; Influenza, Human - immunology; Influenza, Human - virology; Microbiology and Infectious Disease; Middle Aged; Neuraminidase - genetics; Neuraminidase - immunology; Pandemics; Pest outbreaks; Seasons; United States - epidemiology; Viruses; Young Adult; United States; United States > US; global health; epidemiology; infectious disease; antigenic drift; influenza virus; microbiology; human; virus; H3N2

Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected individuals, but the contribution of this process to variability i...