Recognition of Oxidized Lipids by Macrophages and Its Role in Atherosclerosis Development

• Published in: Biomedicines Vol. 9; no. 8; p. 915
• Main Authors: Mushenkova, Nataliya V., Bezsonov, Evgeny E., Orekhova, Varvara A., Popkova, Tatyana V., Starodubova, Antonina V., Orekhov, Alexander N.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.07.2021; MDPI
• Subjects: Apolipoproteins; Arteries; Arteriosclerosis; Atherosclerosis; Cardiovascular disease; Cholesterol; Cytokines; Epitopes; Immune system; immunomodulation; Immunoregulation; Inflammation; LDL; Lipids; Low density lipoprotein; macrophage; Macrophages; Oxidation; oxidized LDL; Particle size; Pathogenesis; Proteins; Review

Atherosclerosis is a multifactorial chronic disease that has a prominent inflammatory component. Currently, atherosclerosis is regarded as an active autoimmune process that involves both innate and adaptive immune pathways. One of the drivers of this process is the presence of modified low-density l...